L. Sharma

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Osteoarthritis: new insights. Part 1: the disease and its risk factors.

Dave T Felson, Renée Lawrence, +17 authors J. F. Fries
Annals of internal medicine
2000

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistry. Evidence is… (More)

Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis.

L. Sharma, Daniel Hurwitz, +6 authors Thomas P. Andriacchi
Arthritis and rheumatism
1998

OBJECTIVE The adduction moment at the knee during gait is the primary determinant of medial-to-lateral load distribution. If the adduction moment contributes to progression of osteoarthritis (OA),… (More)

Knee pain and joint loading in subjects with osteoarthritis of the knee.

Debra E Hurwitz, A R Ryals, Jonathan Block, L. Sharma, Tobias Schnitzer, Thomas P. Andriacchi
Journal of orthopaedic research : official…
2000

Although treatments for osteoarthritis of the knee are often directed at relieving pain, pain may cause patients to alter how they perform activities to decrease the loads on the joints. The… (More)

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis.

L. Torres, Diana Dunlop, +8 authors L. Sharma
Osteoarthritis and cartilage
2006

INTRODUCTION Pain is the most common symptom in knee osteoarthritis (OA), a leading cause of chronic disability, and a major source of the disability attributable to OA in general. Pain severity in… (More)

The mechanism of the effect of obesity in knee osteoarthritis: the mediating role of malalignment.

L. Sharma, Chao Lou, September Cahue, Diana Dunlop
Arthritis and rheumatism
2000

OBJECTIVE Obesity is most strongly linked to osteoarthritis (OA) at the knee. Varus malalignment was examined as a possible local mediator that may increase the impact of body weight at the knee,… (More)

Laxity in healthy and osteoarthritic knees.

L. Sharma, Chao Lou, +5 authors T. S. Buchanan
Arthritis and rheumatism
1999

OBJECTIVE Although it is a cause of osteoarthritis (OA) in animal models, laxity in human knee OA has been minimally evaluated. Ligaments become more compliant with age; whether this results in… (More)

Leg symptoms in peripheral arterial disease: associated clinical characteristics and functional impairment.

Mary Mcgrae McDermott, P. Thornton Greenland, +11 authors Gregory J O Martin
JAMA
2001

CONTEXT Persons with lower-extremity peripheral arterial disease (PAD) are often asymptomatic or have leg symptoms other than intermittent claudication (IC). OBJECTIVE To identify clinical… (More)

Is knee joint proprioception worse in the arthritic knee versus the unaffected knee in unilateral knee osteoarthritis?

L. Sharma, Y C Pai, Kristian Holtkamp, W. Z. Rymer
Arthritis and rheumatism
1997

OBJECTIVE Neuromuscular joint protection requires proprioceptive input and motor output. Impairment of proprioception in knee osteoarthritis (OA) may contribute to, and/or result from, the disease.… (More)

Quadriceps weakness predicts risk for knee joint space narrowing in women in the MOST cohort.

Neil A. Segal, Natalie A Glass, +5 authors C. E. Lewis
Osteoarthritis and cartilage
2010

OBJECTIVE Quadriceps weakness has been reported with incident but not progressive knee osteoarthritis (OA) in longitudinal studies. This study examined the relationship between quadriceps strength… (More)

Trajectory of cartilage loss within 4 years of knee replacement--a nested case-control study from the osteoarthritis initiative.

Felix Eckstein, Roger Boudreau, +11 authors C. K. Kwoh
Osteoarthritis and cartilage
2014

OBJECTIVE Knee replacement (KR) represents a clinically important endpoint of knee osteoarthritis (KOA). Here we examine the 4-year trajectory of femoro-tibial cartilage thickness loss prior to KR vs… (More)

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