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Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity
The obese gene product leptin is an important signaling protein that regulates food intake and body weight via activation of the hypothalamic leptin receptor (Ob-Rb; Jacob et al., 1997). However,Expand
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Leptin inhibits epileptiform‐like activity in rat hippocampal neurones via PI 3‐kinase‐driven activation of BK channels
The obese gene product, leptin is an important circulating satiety factor that regulates energy balance via its actions in the hypothalamus. However, leptin receptors are also expressed in brainExpand
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Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
Leptin is an important circulating factor that regulates energy balance via the leptin receptor Ob-Rb in the hypothalamus. Ob-Rb activation may inhibit hypothalamic neurons by activatingExpand
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Influx of extracellular Ca2+ is necessary for electrotaxis in Dictyostelium
Intracellular free Ca2+ ([Ca2+]i) is a pivotal signalling element in cell migration and is thought to be required for chemotaxis of Dictyostelium. Ca2+ signalling may also be important forExpand
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Leptin: a potential cognitive enhancer?
It is well documented that the hormone leptin signals information regarding the status of fat stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight. However, leptinExpand
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Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels
In this study, we have used a combination of immunocytochemical and Ca(2+) imaging techniques to determine the functional localisation of insulin receptors as well as the potential role for insulinExpand
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The roles of calcium signaling and ERK1/2 phosphorylation in a Pax6+/- mouse model of epithelial wound-healing delay
BackgroundCongenital aniridia caused by heterozygousity at the PAX6 locus is associated with ocular surface disease including keratopathy. It is not clear whether the keratopathy is a direct resultExpand
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Leptin: a potential cognitive enhancer?
It is well documented that the hormone leptin signals information regarding the status of fat stores to hypothalamic nuclei, which in turn control feeding behaviour and body weight. However, leptinExpand
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Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium.
PURPOSE To investigate the effects of insulin and leptin on in vitro wound healing of transformed human corneal epithelial cell monolayers and to identify cellular (migration versus proliferation)Expand
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Long-Range Regulatory Synergy Is Required to Allow Control of the TAC1 Locus by MEK/ERK Signalling in Sensory Neurones
Changes in the expression of the neuropeptide substance P (SP) in different populations of sensory neurones are associated with the progression of chronic inflammatory disease. Thus, understandingExpand
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