Ghrelin enhances appetite and increases food intake in humans.
- A. Wren, L. Seal, S. Bloom
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 December 2001
Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight.
Ghrelin causes hyperphagia and obesity in rats.
Evidence is provided that ghrelin is important in long-term control of food intake and body weight and that circulating gh Relin at fasting concentrations may stimulate food intake.
Non-binary or genderqueer genders
- C. Richards, W. Bouman, L. Seal, M. Barker, T. Nieder, G. T’Sjoen
- SociologyInternational Review of Psychiatry
- 2 January 2016
This paper considers ways in which (mental) health professionals may assist the people with genderqueer and non-binary gender identities and/or expressions they may see in their practice and considers treatment options and associated risks.
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers.
- C. Edwards, S. Stanley, S. Bloom
- MedicineAmerican Journal of Physiology. Endocrinology and…
- 1 July 2001
The results are in accord with the possibility that exendin-4 may be a potential treatment for type 2 diabetes, particularly for obese patients, because it acts to reduce plasma glucose at least partly by a delay in gastric emptying, as well as by reducing calorie intake.
Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone.
- C. Abbott, A. Kennedy, S. Bloom
- BiologyEndocrinology
- 1 September 2003
The studies suggest that the orexigenic effect of MCH may be mediated via activation or inhibition of these feeding circuits within the arcuate nucleus and paraventricular nucleus of the hypothalamus.
The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin.
A role for the hypothalamic melanocortin system is suggested in the fasting-induced suppression of the H-P-T axis and their antagonist, agouti-related peptide (Agrp), can inhibit it.
Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.
It is indicated that the hypothalamic nuclei expressing MC4R vary in their sensitivity to Agrp and alpha-MSH with regard to their effect on feeding, and that the PVN, DMN, and MPO were the areas with the greatest response to A Grp and NDP- MSH.
Hypothalamic Interactions Between Neuropeptide Y, Agouti‐Related Protein, Cocaine‐ and Amphetamine‐Regulated Transcript and Alpha‐Melanocyte‐Stimulating Hormone In Vitro in Male Rats
The results are in keeping with the possibility that the melanocortin‐3 receptor in the arcuate nucleus may influence the release of arcuate neuropeptides, and suggest reinforcing orexigenic behaviour via a positive‐feedback loop.
Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo–pituitary axes in vitro and in vivo in male rats
- S. Stanley, C. Small, S. Bloom
- Biology, MedicineBrain Research
- 2 March 2001
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