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Molecular Imaging Using a Targeted Magnetic Resonance Hyperpolarized Biosensor
A magnetic resonance approach is presented that enables high-sensitivity, high-contrast molecular imaging by exploiting xenon biosensors. These sensors link xenon atoms to specific biomolecularExpand
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Application of magnetic resonance imaging in zoology
Magnetic resonance imaging (MRI) is a noninvasive imaging technique that today constitutes one of the main pillars of preclinical and clinical imaging. MRI’s capacity to depict soft tissue in wholeExpand
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Multichannel MRI labeling of mammalian cells by switchable nanocarriers for hyperpolarized xenon.
We demonstrate a concept for multichannel MRI cell-labeling using encapsulated laser-polarized xenon. Conceptually different Xe trapping properties of two nanocarriers, namely macrocyclic cages asExpand
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Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI
Gas vesicles (GVs) are a unique class of gas-filled protein nanostructures that are detectable at subnanomolar concentrations and whose physical properties allow them to serve as highly sensitiveExpand
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Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations
Significance The field of xenon magnetic resonance imaging (MRI) is moving closer to the development of targeted xenon biosensors for in vivo applications. It is motivated by a ca. 108-fold improvedExpand
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Temperature response of 129Xe depolarization transfer and its application for ultrasensitive NMR detection.
Trapping xenon in functionalized cryptophane cages makes the sensitivity of hyperpolarized (HP) 129Xe available for specific NMR detection of biomolecules. Here, we study the signal transfer onto aExpand
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NMR of hyperpolarised probes.
Increasing the sensitivity of NMR experiments is an ongoing field of research to help realise the exquisite molecular specificity of this technique. Hyperpolarisation of various nuclei is a powerfulExpand
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Slice-selective gradient-encoded CEST spectroscopy for monitoring dynamic parameters and high-throughput sample characterization.
Chemical Exchange Saturation Transfer (CEST) NMR is an increasingly used technique for generating molecule or microenvironment specific signal contrast. To characterize CEST agents and to extractExpand
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Functionalized 129Xe as a potential biosensor for membrane fluidity.
Using spin hyperpolarized xenon ((129)Xe) we investigate the impact of the local molecular environment on reversible host-guest interactions. We label Xe guest atoms that are temporarily bound toExpand
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Ultrafast CEST imaging.
We describe a new MR imaging method for the rapid characterization or screening of chemical exchange saturation transfer (CEST) contrast agents. It is based on encoding the chemical shift dimensionExpand
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