Comparison of PCR Assays for Diagnosis of Cutaneous Leishmaniasis
- Esther Bensoussan, A. Nasereddin, F. Jonas, L. Schnur, C. Jaffe
- Medicine, BiologyJournal of Clinical Microbiology
- 1 April 2006
Three PCR assays for diagnosing leishmaniasis were compared and validated against parasite cultures and microscopic evaluation of stained tissue smears using 92 specimens from suspected cases of cutaneous leish maniasis in Israel and the West Bank, suggesting that a PCR using kDNA should be used for the diagnosis of CL and that an ITS1 PCR can be reliably used when rapid species identification is needed.
An experimental model for canine visceral leishmaniasis
- P. Abranches, G. Santos-Gomes, N. Rachamim, L. Campino, L. Schnur, C. Jaffe
- Biology, MedicineParasite immunology (Print)
- 1 September 1991
Serum antibodies to leishmanial antigens were apparent between 15 to 3 months following challenge and correlated with the appearance of enlarged lymph nodes, hypergammaglobulinaemia and the presence of parasites in tissue biopsies.
Outbreak of cutaneous leishmaniasis in northern Israel.
- R. Jacobson, C. Eisenberger, A. Warburg
- MedicineJournal of Infectious Diseases
- 1 October 2003
The northern part of this emerging focus of cutaneous leishmaniasis in Israel is distinct from all known L. tropica foci, and P. arabicus is the main vector, and it transmits parasites that are different from other L. Tropica isolates, with respect to antigenic, molecular, and biochemical parameters.
Multifarious characterization of leishmania tropica from a Judean desert focus, exposing intraspecific diversity and incriminating phlebotomus sergenti as its vector.
- L. Schnur, A. Nasereddin, A. Warburg
- BiologyAmerican Journal of Tropical Medicine and Hygiene
- 1 April 2004
Results support the heterogeneous nature of L. tropica and incriminate Ph. sergenti as its vector in this Judean Desert focus.
Leishmaniasis in the Jordan Valley II. Sandflies and transmission in the central endemic area.
- Y. Schlein, A. Warburg, L. Schnur, A. Gunders
- BiologyTransactions of the Royal Society of Tropical…
Distinct Transmission Cycles of Leishmania tropica in 2 Adjacent Foci, Northern Israel
- M. Svobodová, J. Votýpka, A. Warburg
- MedicineEmerging Infectious Diseases
- 1 December 2006
Infection with Leishmania tropica is emerging because of encroachment of rock hyraxes and transmission by multiple vector species.
Microsatellite analysis reveals genetic structure of Leishmania tropica.
- J. Schwenkenbecher, T. Wirth, G. Schönian
- BiologyInternational Journal of Parasitology
- 1 February 2006
Detection and Identification of Old World Leishmania by High Resolution Melt Analysis
- D. Talmi-Frank, A. Nasereddin, G. Baneth
- MedicinePLoS Neglected Tropical Diseases
- 1 January 2010
This new assay was able to detect as little as 2-4 ITS1 gene copies in a 5 µl DNA sample, i.e., less than a single parasite per reaction, which is useful for rapid diagnosis of leishmaniasis and simultaneous identification and quantification of the infecting Leishmania species.
Identification of geographically distributed sub-populations of Leishmania (Leishmania) major by microsatellite analysis
- A. Al-Jawabreh, Stephanie Diezmann, G. Schönian
- BiologyBMC Evolutionary Biology
- 24 June 2008
The model- and distance-based analyses of the microsatellite data exposed three main populations of L. (L.) major, Central Asia, the Middle East and Africa, each of which separated into two sub-populations which probably correlates with the different species of rodent host.
Epidemiology, diagnosis and control of leishmaniasis in the Mediterranean region.
- Y. Ozbel, N. Turgay, P. Abranches
- MedicineAnnals of Tropical Medicine and Parasitology
- 1 December 1995
The development of highly sensitive and accurate new tools to facilitate diagnosis and epidemiological surveys of endemic areas and for studies on the immunology of VL in laboratory models will provide a better understanding of the disease and improve its control.