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Influence of pH on wound-healing: a new perspective for wound-therapy?
The conclusion to be drawn at present is that the wound pH indeed proves to be a potent influential factor for the healing process and that different pH ranges are required for certain distinct phases of wound healing. Expand
Solar UV irradiation and dermal photoaging.
A decrease in the overall ROS load by efficient sunscreens or other protective agents may represent promising strategies to prevent or at least minimize ROS-induced photoaging. Expand
Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue
Strategies to prevent or at least minimize ROS‐induced photo‐ageing and intrinsic ageing of the skin necessarily include protection against UV irradiation and antioxidant homeostasis. Expand
Overexpression of Phospholipid-hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts Abrogates UVA Irradiation-induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-1 by
UVA irradiation-induced PCOOHs and subsequent lipid peroxides initiate the NFκB-mediated induction of IL-6, which mediates the induction of MMP-1, and this finding is particularly relevant in light of the already available small molecule mimetics of PHGPx. Expand
UV-induced oxidative stress and photoaging.
Phototherapy and photochemotherapy.
It is pointed out that phototherapy is clearly a first-line therapy that is safe and effective, however, guidelines in the patient management still have to be harmonized, and further trials to improve the fine tuning of irradiation protocols are still necessary. Expand
Vascular endothelial growth factor causally contributes to the angiogenic response upon ultraviolet B irradiation in vivo
Ultraviolet (UV)‐B irradiation has been shown to be an inducer of vascular endothelial growth factor (VEGF) in primary keratinocytes and epidermal cell lines in vitro. Expand
Topical silver and gold nanoparticles complexed with Cornus mas suppress inflammation in human psoriasis plaques by inhibiting NF‐κB activity
Immunofluorescence confirmed that nanoparticles significantly reduced CD68‐positive macrophages and their IL‐12 and TNF‐α production in human psoriasis plaques, and Ag and Au NPs‐CM represent a novel nanoparticle‐based “green” technology which may provide an efficient tool for modern Psoriasis therapy, circumventing immunosuppression‐related side effects of biologicals. Expand
Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes.
The data clarified regulatory mechanisms of UVB-dependent VEGF stimulation which may be critical for angiogenic processes in the skin and supported the critical role of the AP-2/Sp1 (specificity protein 1) cluster. Expand
Improvement of cold urticaria by treatment with the leukotriene receptor antagonist montelukast.
Treatment with montelukast (Singulair), a leukotriene receptor antagonist, signi®cantly improved the urticaria after only 4 days of oral administration at a daily dose of 10 mg, and revealed a substantial suppression of hives to 5% of initial wealing. Expand