L. Schmitt

Publications193
h-index38
Citations4,850
Highly Influential Citations273
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A structural classification of substrate‐binding proteins
Substrate‐binding proteins (SBP) are associated with a wide variety of protein complexes. The proteins are part of ATP‐binding cassette transporters for substrate uptake, ion gradient driven… Expand
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H662 is the linchpin of ATP hydrolysis in the nucleotide‐binding domain of the ABC transporter HlyB
The ABC transporter HlyB is a central element of the HlyA secretion machinery, a paradigm of Type I secretion. Here, we describe the crystal structure of the HlyB‐NBD (nucleotide‐binding domain) with… Expand
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A structural analysis of asymmetry required for catalytic activity of an ABC‐ATPase domain dimer
The ATP‐binding cassette (ABC)‐transporter haemolysin (Hly)B, a central element of a Type I secretion machinery, acts in concert with two additional proteins in Escherichia coli to translocate the… Expand
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Type 1 protein secretion in bacteria, the ABC-transporter dependent pathway (Review)
The relatively simple type 1 secretion system in Gram-negative bacteria is nevertheless capable of transporting polypeptides of up to 800 kDa across the cell envelope in a few seconds. The… Expand
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Crystal structure of the nucleotide-binding domain of the ABC-transporter haemolysin B: identification of a variable region within ABC helical domains.
The ABC-transporter haemolysin B is a central component of the secretion machinery that translocates the toxin, haemolysin A, in a Sec-independent fashion across both membranes of E. coli. Here, we… Expand
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A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5
The yeast ABC transporter Pdr5 plays a major role in drug resistance against a large number of structurally unrelated compounds. Although Pdr5 has been extensively studied, many important aspects… Expand
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De novo bile salt transporter antibodies as a possible cause of recurrent graft failure after liver transplantation: A novel mechanism of cholestasis
Progressive familial intrahepatic cholestasis type 2 (PFIC‐2) is caused by mutations of the bile salt export pump (BSEP [ABCB11]), an ATP‐binding cassette (ABC)‐transporter exclusively expressed at… Expand
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Molecular determinants for substrate specificity of the ligand-binding protein OpuAC from Bacillus subtilis for the compatible solutes glycine betaine and proline betaine.
Compatible solutes play a decisive role in the defense of microorganisms against changes in temperature and increases in osmolarity in their natural habitats. In Bacillus subtilis, the… Expand
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The Type 1 secretion pathway - the hemolysin system and beyond.
Type 1 secretion systems (T1SS) are wide-spread among Gram-negative bacteria. An important example is the secretion of the hemolytic toxin HlyA from uropathogenic strains. Secretion is achieved in a… Expand
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The motor domains of ABC-transporters. What can structures tell us?
The transport of substrates across a cellular membrane is a vitally important biological function essential for cell survival. ATP-binding cassette (ABC) transporters constitute one of the largest… Expand
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