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High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial.
TLDR
Treatment with HVP improves outcome in patients with ALF by increasing liver transplantation-free survival by attributable to attenuation of innate immune activation and amelioration of multi-organ dysfunction. Expand
MELD score as a predictor of liver failure and death in patients with acetaminophen‐induced liver injury
TLDR
MELD score may be useful as a predictors of FHF in patients admitted with acetaminophen toxicity, however, as a predictor of death from FHF, MELD score did not provide more information than the King's College Hospital criteria or INR alone. Expand
Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure*
TLDR
The study confirmed arterial lactate as a prognostic marker in acetaminophen-induced fulminant hepatic failure and confirmed the lactate modification of the King’s College Hospital criteria showed no obvious advantages over the existing selection criteria. Expand
Serum phosphate is an early predictor of outcome in severe acetaminophen‐induced hepatotoxicity
TLDR
It is proposed that hyperphosphatemia after acetaminophen overdose is caused by renal dysfunction in the absence of hepatic regeneration, as the latter appears to be associated with lowering of serum phosphate. Expand
Acute versus chronic alcohol consumption in acetaminophen‐induced hepatotoxicity
TLDR
It is suggested that patients with chronic alcoholism and suspected acetaminophen poisoning due to an increased risk of developing hepatotoxicity should be treated with NAC regardless of risk estimation. Expand
Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning.
TLDR
Asthma must be considered a risk factor in the development of side-effects to N-acetylcysteine and there is no reason to withhold NAC from any patient with paracetamol poisoning. Expand
Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury
TLDR
Assessment of the effect of intravenous acetylcysteine on the prothrombin index in patients with paracetamol poisoning without signs of hepatocellular injury found it to be strongly associated with the start of acetylCysteine infusion. Expand
Effect of intravenous N-acetylcysteine infusion on haemostatic parameters in healthy subjects
TLDR
Therapeutic doses of N-acetylcysteine cause abnormal haemostatic activity, and this should be taken into account when using haemOSTatic function tests as an indicator of hepatic injury. Expand
Alpha‐fetoprotein is a predictor of outcome in acetaminophen‐induced liver injury
TLDR
It is suggested that the introduction of highly sensitive EIAs for the detection of AFP will require a reevaluation of AFP as a prognostic marker in acute nonneoplastic liver disease. Expand
Effect of treatment with the Molecular Adsorbents Recirculating System on arterial amino acid levels and cerebral amino acid metabolism in patients with hepatic encephalopathy
TLDR
Even though the overall reduction in plasma amino acids and improvement in amino acid dysbalance may well be beneficial, it was not accompanied by any immediate improvement in cerebral amino acid metabolism in patients with FHF or AoCLF. Expand
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