• Publications
  • Influence
Similarities and differences between selective and nonselective BAFF blockade in murine SLE.
B cells have multiple roles in immune activation and inflammation separate from their capacity to produce antibodies. B cell depletion is currently under intense investigation as a therapeuticExpand
  • 208
  • 6
  • PDF
Activated Renal Macrophages Are Markers of Disease Onset and Disease Remission in Lupus Nephritis1
Costimulatory blockade with CTLA4Ig and anti-CD40L along with a single dose of cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice. To understand theExpand
  • 163
  • 6
  • PDF
Proinflammatory Effects of Tweak/Fn14 Interactions in Glomerular Mesangial Cells1
TNF-like weak inducer of apoptosis, or TWEAK, is a relatively new member of the TNF-ligand superfamily. Ligation of the TWEAK receptor Fn14 by TWEAK has proinflammatory effects on fibroblasts,Expand
  • 143
  • 5
Short Term Administration of Costimulatory Blockade and Cyclophosphamide Induces Remission of Systemic Lupus Erythematosus Nephritis in NZB/W F1 Mice by a Mechanism Downstream of Renal Immune Complex
NZB/W F1 mice with established nephritis were treated with a single dose of cyclophosphamide with or without a 2-wk course of murine CTLA4Ig, either alone or in combination with anti-CD154. Sixty toExpand
  • 111
  • 4
  • PDF
Inhibitory Smads and TGF-β Signaling in Glomerular Cells
ABSTRACT. Smad6 and Smad7 are inhibitory SMADs with putative functional roles at the intersection of major intracellular signaling networks, including TGF-β, receptor tyrosine kinase (RTK), JAK/STAT,Expand
  • 72
  • 4
  • PDF
Inhibitory smads and tgf-Beta signaling in glomerular cells.
Smad6 and Smad7 are inhibitory SMADs with putative functional roles at the intersection of major intracellular signaling networks, including TGF-beta, receptor tyrosine kinase (RTK), JAK/STAT, andExpand
  • 40
  • 4
Mechanism of Action of Transmembrane Activator and Calcium Modulator Ligand Interactor-Ig in Murine Systemic Lupus Erythematosus1
B cell-activating factor belonging to the TNF family (BAFF) blockade prevents the onset of disease in systemic lupus erythematosus (SLE)-prone NZB/NZW F1 mice. To determine the mechanism of thisExpand
  • 134
  • 3
  • PDF
CXCL13 in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
BackgroundChemokine CXC ligand 13 (CXCL13) has been implicated in perivascular inflammation and pulmonary vascular remodeling in patients with idiopathic pulmonary artery hypertension (IPAH). WeExpand
  • 13
  • 2
...
1
2
3
4
5
...