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Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo.
BACKGROUND/AIMS Intense pruritus and the risk of stillbirths and premature deliveries justify the search for an effective pharmacologic treatment of intrahepatic cholestasis of pregnancy. This studyExpand
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Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile.
BACKGROUND/AIMS Low blood Se levels have been previously shown in normal pregnancies (third trimester) and significantly lower levels in patients with intrahepatic cholestasis of pregnancy (ICP), inExpand
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Acute fatty liver of pregnancy: a clinical study of 12 episodes in 11 patients.
Twelve episodes of acute fatty liver of pregnancy (AFLP) were diagnosed in 11 patients during the past 18 years in a general hospital in Santiago, Chile, with a prevalence of 1 per 15,900 deliveries.Expand
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Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy.
  • R. Zapata, L. Sandoval, +6 authors Juan Jorge Silva
  • Medicine
  • Liver international : official journal of the…
  • 1 June 2005
Abstract: Objective: To assess the efficacy of ursodeoxycholic acid (UDCA) in patients with intrahepatic cholestasis of pregnancy (ICP) and in the outcome of pregnancy.
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Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?
Increased gastrointestinal permeability has been demonstrated in several liver diseases. It may facilitate the absorption of gut‐derived endotoxin‐stimulating Kupffer cells to release proinflammatoryExpand
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