• Publications
  • Influence
Ocular inserts for topical delivery
Abstract In spite of extensive pharmacological and clinical data pointing to the usefulness and advantages of solid devices for topical drug delivery to the eye, liquid, and to a smaller extent,Expand
  • 162
  • 4
Corneal Models for the Toxicity Testing of Drugs and Drug Releasing Materials
Summary T he Draize rabbit eye irritation test developed in the 1940’s is even today the only eye toxicity test officially accepted in the OECD countries for regulatory purposes in the classificationExpand
  • 25
  • 4
Review: systemic absorption of topically applied ocular drugs in humans.
Literature on human plasma concentrations after instillation of ocular timolol, levobunolol, atropine, cyclopentolate, scopolamine, phenylephrine, betamethasone and technetium Tc 99m and theories ofExpand
  • 103
  • 2
Systemic and ocular absorption and antagonist activity of topically applied cyclopentolate in man.
Ocular and systemic absorption and antagonist activity of topical 1% cyclopentolate were studied in 11 elderly patients undergoing extracapsular cataract extraction, and in 8 healthy femaleExpand
  • 32
  • 2
Acoustic emission from paper fracture.
We report tensile failure experiments on paper sheets. The acoustic emission energy and the waiting times between acoustic events follow power-law distributions. This remains true while the strainExpand
  • 108
  • 2
  • PDF
Animal pharmacokinetic studies
  • 17
  • 2
Systemic absorption of ocular pilocarpine is modified by polymer matrices
Abstract Systemic absorption of ocularly applied pilocarpine (1.2 mg) was studied after administration in aqueous solution, in hydroxypropylcellulose (HPC) matrix, and in a matrix of n -butylExpand
  • 65
  • 1
Systemic absorption of ophthalmic cyclopentolate.
  • 21
  • 1
Evaluation of the cytotoxicity of selected systemic and intravitreally dosed drugs in the cultures of human retinal pigment epithelial cell line and of pig primary retinal pigment epithelial cells.
The cytotoxicity of the selected systemic and intravitreally dosed drugs tamoxifen, toremifene, chloroquine, 5-fluorouracil, gentamicin and ganciclovir was studied in retinal pigment epithelium (RPE)Expand
  • 31
  • 1
Timolol binding to bovine ocular melanin in vitro.
The binding characteristics of 3H-timolol to bovine iris melanin were determined by using a ligand binding assay. The association and dissociation kinetics were performed using 100 nM 3H-timolol andExpand
  • 9
  • 1