• Publications
  • Influence
Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections.
  • G. Pankey, L. Sabath
  • Medicine, Biology
    Clinical infectious diseases : an official…
  • 15 March 2004
Although bacteriostatic/bactericidal data may provide valuable information on the potential action of antibacterial agents in vitro, it is necessary to combine this information with pharmacokinetic and pharmacodynamic data to provide more meaningful prediction of efficacy in vivo.
Some factors that alter the degree or extent of methicillin resistance within populations of naturally occurring methicillin-resistant (M-R) strains of Sraphylococcus aureus are evaluated in this
Effect of protein A on staphylococcal opsonization
It is proposed that when IgG is not present in the opsonic medium, cell wall protein A is capable of activating complement at the bacterial surface and thereby opsonization is promoted.
Mechanisms of resistance to beta-lactam antibiotics in strains of Staphylococcus aureus.
  • L. Sabath
  • Biology, Medicine
    Annals of internal medicine
  • 1 September 1982
Tolerance is clearly due to decreased autolytic enzyme activity (reflecting persistence of an enzyme inhibitor) of those tolerant organisms that need 32 (or more) times as much antibiotic for a bactericidal effect as for simple inhibition.
Laboratory Evaluation of a Rapid, Automated Susceptibility Testing System: Report of a Collaborative Study
Comparisons of the Autobac 1 and disk diffusion methods showed that both methods gave levels of agreement with the International Collaborative Study agar dilution technique that were generally high and equivalent.
Cephalosporinase and penicillinase activities of a beta-lactamase from Pseudomonas pyocyanea.
The latter might show synergism with the enzyme inhibitors, methicillin and cloxacillin, against this organism, and it was concluded that the production of a beta-lactamase contributed to the factors responsible for the very high resistance of Ps.
Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins.
Eight strains of three genera isolated at Boston City Hospital or Institut Pasteur, Paris, showed antagonism of carbenicillin or ampicillin by cephaloridine, cloxacillin, or 6-aminopenicillanic acid, suggesting that two or more receptor sites of action for penicillins were present.
Susceptibility of "enterobacteria" to aminoglycoside antibiotics: comparisons with tetracyclines, polymyxins, chloramphenicol, and spectinomycin.
Strains of enterobacteria, including common, aerobic, pathogenic gram-negative bacilli, and enterococci were tested for susceptibility to 11 aminoglycoside antibiotics by a twofold agar-dilution method with an inocula replicator with some exceptions related to individual strains of species.