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Theoretical and Practical Approaches for Prediction of Drug–Polymer Miscibility and Solubility
The thermodynamics of API-polymer systems can be modeled using solution based theories and can contribute towards providing an understanding of the compatibility between API and polymer and the mechanisms of physical stabilization in such systems. Expand
A classification system to assess the crystallization tendency of organic molecules from undercooled melts.
The DSC screening method and classification scheme may be a useful tool to quickly assess the glass forming ability (GFA) and potential GS of new chemical entities during early drug development. Expand
Estimation of Drug–Polymer Miscibility and Solubility in Amorphous Solid Dispersions Using Experimentally Determined Interaction Parameters
Experimental models which allow for more quantitative estimates of the thermodynamics of mixing amorphous drugs with glassy polymers provide insight into the physical stability of drug–polymer mixtures and the thermodynamic driving force for crystallization. Expand
Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions
A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers. Expand
Evaluation of amorphous solid dispersion properties using thermal analysis techniques.
Although differential scanning calorimetry is the most widely used thermal analytical technique applied to the characterization of amorphous solid dispersions, there are many established and emerging techniques which have been shown to provide useful information. Expand
Effect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipine.
All polymers appeared to reduce the crystal growth rates of felodipine at an equivalent supersaturation and this mechanism most likely contributes to the enhanced solution concentration values observed during dissolution of the amorphous solid dispersions. Expand
Influence of different polymers on the crystallization tendency of molecularly dispersed amorphous felodipine.
It was found that each polymer was able to significantly decrease the nucleation rate of amorphous felodipine even at low concentrations (3-25% w/w), and hydrogen bonding interactions were formed between felodIPine and each of the polymers. Expand
Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution
The dissolution advantage of amorphous solids can be negated either by crystallization of the isomorphous solid on contact with the dissolution medium or through rapid crystallizationof the supersaturated solution. Expand
Dissolution and precipitation behavior of amorphous solid dispersions.
The supersaturation generated upon dissolution of the solid dispersions was maintained for biologically relevant timeframes for the HPMC dispersions, whereas PVP appeared to be a less effective crystallization inhibitor. Expand
Understanding Polymer Properties Important for Crystal Growth Inhibition—Impact of Chemically Diverse Polymers on Solution Crystal Growth of Ritonavir
The use of supersaturating dosage forms, such amorphous dispersions, is an increasingly common approach for improving delivery of poorly water-soluble drugs. Crystallization must be prevented toExpand