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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome
Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and trafficking. Here we show that Snx27−/− mice have severe neuronal deficits in the hippocampus andExpand
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TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation*
The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in invasive breastExpand
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Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-Methyl-d-Aspartate Receptor 2C (NR2C) ‡
ABSTRACT Phox (PX) domain-containing sorting nexins (SNXs) are emerging as important regulators of endocytic trafficking. Sorting nexin 27 (SNX27) is unique, as it contains a PDZ (Psd-95/Dlg/ZO1)Expand
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A role for sorting nexin 27 in AMPA receptor trafficking
Sorting nexin 27 (SNX27), a PDZ domain-containing endosomal protein, was recently shown to modulate glutamate receptor recycling in Down’s syndrome. However, the precise molecular role of SNX27 inExpand
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Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon
We describe here a molecular genetic approach for imaging synaptic inhibition. The thy-1 promoter was used to express high levels of Clomeleon, a ratiometric fluorescent indicator for chloride ions,Expand
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A role for endobrevin/VAMP8 in CTL lytic granule exocytosis
CTL clear virus‐infected cells and tumorigenic cells by releasing potent cytotoxic enzymes stored in preformed lytic granules. The exocytosis process includes polarization of lytic granules towardExpand
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An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally. The identity and role of cell surface molecules driving complex biological events leading to HCCExpand
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p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport
p125A is an accessory protein for COPII-mediated vesicle budding that links the Sec13/Sec31 and Sec23/24 subcomplexes.
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Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth
The endocytic protein SNX27 functions to link the parathyroid hormone receptor (PTHR) to the retromer trafficking complex. Loss of SNX27 in mice leads to overactive PTHR signaling and reducedExpand
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Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor
Although many proteins have been shown to participate in ligand‐stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocyticExpand
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