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Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.
Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that the SS18-SSX fusion… Expand
A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells
TGFB2-OT1 (TGFB2 overlapping transcript 1) is a newly discovered long noncoding RNA (lncRNA) derived from the 3′UTR of TGFB2. It can regulate autophagy in vascular endothelial cells (VECs). However,… Expand
Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells
MTOR, a central regulator of autophagy, is involved in cancer and cardiovascular and neurological diseases. Modulating the MTOR signaling balance could be of great significance for numerous diseases.… Expand
Differences between plasma and adipose tissue biomarkers of carotenoids and tocopherols.
- L. Sự, M. Bui, +9 authors L. Kohlmeier
- Cancer epidemiology, biomarkers & prevention : a…
- 1 November 1998
Biomarkers of dietary exposure or nutritional status are sought actively to overcome limitations of traditional dietary methodology. We compared plasma and adipose tissue biomarkers for carotenoids… Expand
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is persistently activated in many human tumors including acute myeloid leukemia (AML). Therefore, inhibition of Nrf2 activity may be a promising… Expand
Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma.
- Joanna M. Lubieniecka, D. D. de Bruijn, +6 authors T. Nielsen
- Biology, Medicine
- Cancer research
- 1 June 2008
Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional cofactors involved in activation and repression… Expand
TIA1 interacts with annexin A7 in regulating vascular endothelial cell autophagy.
- Shuya Huang, N. Liu, +6 authors J. Miao
- Chemistry, Medicine
- The international journal of biochemistry & cell…
- 1 December 2014
T-cell intracellular antigen-1 (TIA1) is a DNA/RNA binding protein broadly expressed in eukaryotic cells, participating in multiple aspects of cellular metabolism. TIA1 phosphorylation was related… Expand
Safrole oxide induces neuronal apoptosis through inhibition of integrin beta4/SOD activity and elevation of ROS/NADPH oxidase activity.
Neuronal apoptosis is a very important event in the development of the central nervous system (CNS), but the underlying mechanisms remain to be elucidated. We have previously shown that safrole… Expand
Activating transcription factor 2 in mesenchymal tumors.
Activating transcription factor 2 (ATF2) is a member of activator protein 1 superfamily, which can heterodimerize with other transcription factors regulating cell differentiation and survival. ATF2… Expand
Rapid STAT Phosphorylation via the B Cell Receptor
Engagement of the B cell receptor (BCR) initiates multiple signaling cascades which mediate different biological responses, depending on the stage of B cell differentiation, antigen binding affinity,… Expand