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Epoxide opening versus silica condensation during sol-gel hybrid biomaterial synthesis.
Hybrid organic-inorganic solids represent an important class of engineering materials, usually prepared by sol-gel processes by cross-reaction between organic and inorganic precursors. The choice ofExpand
Glycosylation and Integrin Regulation in Cancer.
Integrins are transmembrane receptors that coordinate extracellular matrix (ECM)-cell and cell-cell interactions, signal transmission, gene expression, and cell function. The aberration of integrinExpand
VA-086 methacrylate gelatine photopolymerizable hydrogels: A parametric study for highly biocompatible 3D cell embedding.
The ability to replicate in vitro the native extracellular matrix (ECM) features and to control the three-dimensional (3D) cell organization plays a fundamental role in obtaining functionalExpand
Kdo: a critical monosaccharide for bacteria viability.
Covering: 2000 to 2010 Kdo belongs to the 3-deoxysugar ‘family’ and is a critical monosaccharidic component of lipopolysaccharides (LPSs) in Gram-negative bacteria. The incorporation of Kdo intoExpand
Carbonate hydroxyapatite functionalization: a comparative study towards (bio)molecules fixation
Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improveExpand
Multivalent ligand mimetics of LecA from P. aeruginosa: synthesis and NMR studies.
Molecular recognition of glycans plays an important role in glycomic and glycobiology studies. For example, pathogens have a number of different types of lectin for targeting host sugars. InExpand
Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry.
Several glycoprocessing enzymes and glycoreceptors have been recognized as important targets for therapeutic intervention. This concept has inspired the development of important classes ofExpand
Glucosamine grafting on poly(ε-caprolactone): a novel glycated polyester as a substrate for tissue engineering
Poly(e-caprolactone), PCL, has been functionalized with a biologically relevant monosaccharide, i.e. glucosamine, in a single step process after material fabrication. Glucosamine-functionalised PCLExpand
Galactose grafting on poly(ε-caprolactone) substrates for tissue engineering: a preliminary study.
The grafting of galactose units onto poly(ε-caprolactone) (PCL) substrates by a wet chemistry two-step procedure is proposed. Even though a reduction of hardness from 0.58-0.31 GPa to 0.12-0.05 GPaExpand
Thiol-ene mediated neoglycosylation of collagen patches: a preliminary study.
Despite the relevance of carbohydrates as cues in eliciting specific biological responses, the covalent surface modification of collagen-based matrices with small carbohydrate epitopes has beenExpand