Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation.
- J. Torday, H. Sun, L. Wang, E. Torres, M. Sunday, L. Rubin
- Biology, MedicineAmerican Journal of Physiology - Lung cellular…
- 1 March 2002
It is shown that PTHrP paracrine stimulation of type II cell maturation requires leptin expression by lipofibroblasts, the first demonstration of aParacrine loop that functionally cooperates to induce alveolar acinar lung development.
Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH.
- O. K. Davis, D. Hawkins, L. Rubin, J. Posillico, E. Brown, I. Schiff
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 October 1988
The findings suggest, in contrast with the results of most previous studies, that serum intact PTH may decline during pregnancy.
Role of macular xanthophylls in prevention of common neovascular retinopathies: retinopathy of prematurity and diabetic retinopathy.
Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants
Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants and may decrease inflammation, point to protective effects of lutein on preterm retina health and maturation.
Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway.
- J. Sanchez-Esteban, Yulian Wang, P. Gruppuso, L. Rubin
- BiologyAmerican Journal of Respiratory Cell and…
It is concluded that stretch, at least in part, induces differentiation of fetal epithelial cells via EGFR activation of the ERK pathway, which suggests that EGFR may be a mechanosensor during fetal lung development.
Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms
Dietary lutein supplementation may be a promising alternative and/or adjunct therapeutic candidate against breast cancer through increased cell type-specific ROS generation and alternation of several signaling pathways.
Cyclic mechanical stretch inhibits cell proliferation and induces apoptosis in fetal rat lung fibroblasts.
- J. Sanchez-Esteban, Yulian Wang, L. Cicchiello, L. Rubin
- BiologyAmerican Journal of Physiology - Lung cellular…
- 1 March 2002
Mechanical stretch of fibroblasts isolated during the canalicular stage inhibits cell cycle progression and activates apoptosis, and these findings are cotemporal with the mesenchymal thinning that normally occurs in situ.
Variation among neonatal intensive care units in narcotic administration.
- D. Kahn, D. Richardson, D. Pursley
- MedicineArchives of Pediatrics & Adolescent Medicine
- 1 September 1998
The study found a 28.6-fold variation among NICUs in narcotic administration in very low-birth-weight neonates, and the need for randomized trials to rationalize these widely differing practices is indicated.
Inhibition of placental 11beta-hydroxysteroid dehydrogenase type 2 by catecholamines via alpha-adrenergic signaling.
- S. Sarkar, S. Tsai, T. Nguyen, M. Plevyak, J. Padbury, L. Rubin
- BiologyAmerican Journal of Physiology. Regulatory…
The results suggest the NE/E-mediated decrease in placental 11betaHSD2 gene expression is an instance of alpha-adrenoceptor-specific rapid transcriptional inhibition of an adrenergic target gene, which may be involved in the deleterious effects of antenatal physiological stress on fetoplacental growth and development.
Evidence for Human Placental Synthesis of 24,25-Dihydroxyvitamin D3 and 23,25-Dihydroxyvitamin D3
- L. Rubin, B. Yeung, P. Vouros, L. M. Vilner, G. Reddy
- Biology, ChemistryPediatric Research
- 1 July 1993
The identification of this high basal 24-Hydroxylase activity in trophoblast may explain inconsistencies among previous reports regarding placental 1,25(OH)2D3 production and speculate that active placental 24-hydroxylation may serve important functions in perinatal vitamin D metabolism.