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A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
When microinjected into sympathetic neurons, an expression vector for a c-Jun dominant negative mutant protects them against NGF withdrawal-induced death, indicating that AP-1 activity is essential for neuronal cell death. Expand
The cell biology of the blood-brain barrier.
This review concentrates on a cell biological analysis of the blood-brain barrier, with an emphasis on regulation of the specialized intercellular junctions. Expand
A paracrine requirement for hedgehog signalling in cancer
It is shown that, although previous reports have described a cell-autonomous role for Hh signalling in these tumours, Hh ligands fail to activate signalling in tumour epithelial cells, and data support ligand-dependent activation of the Hh pathway in the stromal microenvironment. Expand
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
- M. Frank-Kamenetsky, Xiaoyan M. Zhang, +9 authors J. A. Porter
- Biology, Medicine
- Journal of biology
- 6 November 2002
A synthetic non-peptidyl small molecule is identified and characterized that acts as an agonist of the Hh pathway and raises the possibility that Hh signaling may be regulated by endogenous small molecules in vivo and provide potent compounds with which to test the therapeutic value of activating the HH-signaling pathway in the treatment of traumatic and chronic degenerative conditions. Expand
Targeting the Hedgehog pathway in cancer
This work focuses here on the Hedgehog pathway, which is abnormally activated in most basal cell carcinomas, and discusses potential therapeutic opportunities offered by the progress made in understanding this signalling pathway. Expand
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.
High-content chemical screening is used to identify small molecules that can replace Sox2 in reprogramming and it is found that one of these molecules functions inReprogramming by inhibiting Tgf-beta signaling in a stable and trapped intermediate cell type that forms during the process. Expand
A cell culture model of the blood-brain barrier
A cell culture model of the blood-brain barrier is established by treating brain endothelial cells with a combination of astrocyte-conditioned medium and agents that elevate intracellular cAMP, potentially providing the basis for increasing the penetration of drugs into the central nervous system. Expand
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
It is shown that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice, and that GDF11 alone can improve the cerebral vasculature and enhance Neurogenesis. Expand
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
The development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish are reported and it is found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors. Expand
Occludin as a possible determinant of tight junction permeability in endothelial cells.
It is shown that occludin is present at high levels and is distributed continuously at cell-cell contacts in brain endothelial cells, and developmentally regulated, being low in rat brain endothelia at postnatal day 8 but clearly detectable at post-natal day 70. Expand