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Initial sequencing and analysis of the human genome.
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce andExpand
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The evolution of vertebrate Toll-like receptors.
The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure forExpand
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Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing
  • J. Roach, Gustavo Glusman, +12 authors D. Galas
  • Biology, Medicine
  • Science
  • 30 April 2010
Runs in the Family The power to detect mutations involved in disease by genome sequencing is enhanced when combined with the ability to discover specific mutations that may have arisen betweenExpand
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Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase vertebrate genome, repetitive DNAExpand
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A Genomic Regulatory Network for Development
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo isExpand
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Genetic divergence of the rhesus macaque major histocompatibility complex.
The major histocompatibility complex (MHC) is comprised of the class I, class II, and class III regions, including the MHC class I and class II genes that play a primary role in the immune responseExpand
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The Complete 685-Kilobase DNA Sequence of the Human β T Cell Receptor Locus
The human β T cell receptor (TCR) locus, comprising a complex family of genes, has been sequenced. The locus contains two types of coding elements—TCR elements (65 variable gene segments and twoExpand
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Reverse Engineering of Biological Complexity
www.sciencemag.org (this information is current as of January 8, 2009 ): The following resources related to this article are available online atExpand
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Comparative genomics of the human and mouse T cell receptor loci.
The availability of the complete genomic sequences of the human and mouse T cell receptor loci opens up new opportunities for understanding T cell receptors (TCRs) and their genes. The fullExpand
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Unusual gene order and organization of the sea urchin hox cluster.
While the highly consistent gene order and axial colinear patterns of expression seem to be a feature of vertebrate hox gene clusters, this pattern may be less well conserved across the rest of theExpand
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