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Initial sequencing and analysis of the human genome.
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and… Expand
The evolution of vertebrate Toll-like receptors.
- J. Roach, Gustavo Glusman, +5 authors A. Aderem
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 5 July 2005
The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for… Expand
Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing
Runs in the Family The power to detect mutations involved in disease by genome sequencing is enhanced when combined with the ability to discover specific mutations that may have arisen between… Expand
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase vertebrate genome, repetitive DNA… Expand
A Genomic Regulatory Network for Development
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is… Expand
Genetic divergence of the rhesus macaque major histocompatibility complex.
- Riza Daza-Vamenta, Gustavo Glusman, L. Rowen, B. Guthrie, D. Geraghty
- Biology, Medicine
- Genome research
- 1 August 2004
The major histocompatibility complex (MHC) is comprised of the class I, class II, and class III regions, including the MHC class I and class II genes that play a primary role in the immune response… Expand
The Complete 685-Kilobase DNA Sequence of the Human β T Cell Receptor Locus
The human β T cell receptor (TCR) locus, comprising a complex family of genes, has been sequenced. The locus contains two types of coding elements—TCR elements (65 variable gene segments and two… Expand
Reverse Engineering of Biological Complexity
www.sciencemag.org (this information is current as of January 8, 2009 ): The following resources related to this article are available online at… Expand
Comparative genomics of the human and mouse T cell receptor loci.
The availability of the complete genomic sequences of the human and mouse T cell receptor loci opens up new opportunities for understanding T cell receptors (TCRs) and their genes. The full… Expand
Unusual gene order and organization of the sea urchin hox cluster.
- R. A. Cameron, L. Rowen, +10 authors L. Hood
- Medicine, Biology
- Journal of experimental zoology. Part B…
- 15 January 2006
While the highly consistent gene order and axial colinear patterns of expression seem to be a feature of vertebrate hox gene clusters, this pattern may be less well conserved across the rest of the… Expand