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Phase I Study of the Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, in Combination with Temozolomide in Patients with Advanced Solid Tumors
Purpose: One mechanism of tumor resistance to cytotoxic therapy is repair of damaged DNA. Poly(ADP-ribose) polymerase (PARP)-1 is a nuclear enzyme involved in base excision repair, one of the fiveExpand
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Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development.
The Wnt genes are known to play fundamental roles during patterning and development of a number of embryonic structures. Receptors for Wnts are members of the Frizzled family of proteins containing aExpand
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Wnt signalling regulates myogenic differentiation in the developing avian wing
The limb musculature arises by delamination of premyogenic cells from the lateral dermomyotome. Initially the cells express Pax3 but, upon entering the limb bud, they switch on the expression of MyoDExpand
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Phase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancer.
PURPOSE To establish the maximum-tolerated dose and evaluate tolerability, pharmacokinetics, pharmacodynamic effects, and antitumor activity of AEG35156, a second-generation antisense to X-linkedExpand
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Sonic Hedgehog (SHH) specifies muscle pattern at tissue and cellular chick level, in the chick limb bud
Development of the musculature in chick limbs involves tissue and cellular patterning. Patterning at the tissue level leads to the precise arrangement of specific muscles; at the cellular levelExpand
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Tissue and cellular patterning of the musculature in chick wings.
Development of the musculature involves generation of a precise number of individual muscles arranged in appropriate locations, each with the correct cellular patterning. To find out the rules thatExpand
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Experimental analysis of the control of expression of the homeobox-gene Msx-1 in the developing limb and face.
Mouse mesenchyme was grafted into chick embryos to investigate the control of mesenchymal expression of Msx-1 in the developing limb and face. In situ hybridization, using species-specific probes,Expand
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Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm
The T‐box transcription factor Tbx1 has been implicated in DiGeorge syndrome, the most frequent syndrome due to a chromosomal deletion. Gene inactivation of Tbx1 in mice results in craniofacial andExpand
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Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis.
Wnt signaling has been implicated in somite, limb, and branchial arch myogenesis but the mechanisms and roles are not clear. We now show that Wnt signaling via Lef1 acts to regulate the number ofExpand
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SOLID VARIANT OF ALVEOLAR RHABDOMYOSARCOMA WITH UNBALANCED t(2;13) AND HYPOTETRAPLOIDY, WITHOUT MYCN AMPLIFICATION
Summary The histological subtype of alveolar rhabdomyosarcoma (AR) is characterised by the cytogenetic translocation t(2;13)(q35;q14) in ˜ 70% of cases, a rearrangement rarely present in theExpand
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