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Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Ketamine, a racemic mixture consisting of (S)- and (R)-ketamine, has been in clinical use since 1970. Although best characterized for its dissociative anesthetic properties, ketamine also exertsExpand
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Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice
Abstract Exposure to stress is highly correlated with the emergence of mood-related illnesses. Because major depressive disorder often emerges in adolescence, we assessed the effects of social defeatExpand
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Fluoxetine Exposure during Adolescence Alters Responses to Aversive Stimuli in Adulthood
The mechanisms underlying the enduring neurobiological consequences of antidepressant exposure during adolescence are poorly understood. Here, we assessed the long-term effects of exposure toExpand
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Fluoxetine exposure during adolescence increases preference for cocaine in adulthood
Currently, there is a high prevalence of antidepressant prescription rates within juvenile populations, yet little is known about the potential long-lasting consequences of such treatments,Expand
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Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility
Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum [nucleusExpand
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Vicarious Social Defeat Stress Induces Depression-Related Outcomes in Female Mice
BACKGROUND Stress is a prevailing risk factor for mood-related illnesses, wherein women represent the majority of those affected by major depression. Despite the growing literature suggesting thatExpand
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Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile socialExpand
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(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism
Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) retains the rapid and sustained antidepressant-like actions of ketamine, but is spared its dissociative-like properties and abuseExpand
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