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Acid sphingomyelinase activity triggers microparticle release from glial cells
TLDR
The results represent the first demonstration that activation of acid sphingomyelinase is necessary and sufficient for microparticle release from glial cells and define key molecular effectors of microparticles formation and IL‐1β release, thus, opening new strategies for the treatment of neuroinflammatory diseases. Expand
Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
TLDR
The aim of the study was to evaluate whether MVs are released by microglia/macrophages in vivo and whether their number varies in brain inflammatory conditions, such as multiple sclerosis. Expand
Brain neuronal nicotinic receptors as new targets for drug discovery.
TLDR
The molecular basis of brain nAChR structural and functional diversity mainly in pharmacological and biochemical terms is discussed, and current knowledge concerning the newly discovered drugs used to classify the numerous receptor subtypes and treat the brain diseases in which nA ChRs are involved is summarised. Expand
Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience.
TLDR
The retina is the rat neural region that expresses the widest array of nAChR subtypes, and these receptors have a specific distribution, and their expression is finely regulated during development and by visual experience. Expand
Expression of Nigrostriatal α6-Containing Nicotinic Acetylcholine Receptors Is Selectively Reduced, but Not Eliminated, by β3 Subunit Gene Deletion
TLDR
The results of these experiments show that the β3 subunit is important for the correct assembly, stability and/or transport of α6* nAChRs in dopaminergic neurons and influences their subunit composition, but is not essential for the expression of α 6*, high-affinity α-CtxMII binding nA ChRs. Expand
Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
TLDR
This study demonstrates distinct combinations of subunits contributing to heteromeric nicotinic receptor binding in the human brain that are area/pathway specific and differentially affected by neurodegeneration. Expand
Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
TLDR
Analysis of spontaneous release of glutamate in neurons exposed to MVs found a dose‐dependent increase in miniature excitatory postsynaptic current (mEPSC) frequency without changes in mEpsC amplitude, and identifies microglia‐derived MVs as a new mechanism by which microglian influence synaptic activity. Expand
Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma
TLDR
Evidence is found that MSCs can drive the M transcriptional environment and induce the acquisition of an early, persistent M2-beneficial phenotype both in vivo and in vitro. Expand
TI‐VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes
TLDR
Morphological and functional evidence suggest that besides secretory granules, secretory lysosomes release ATP, which is the main transmitter stored and released from astrocytes under physiological and pathological conditions. Expand
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice
TLDR
Findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. Expand
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