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The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.
BACKGROUND AND AIMS The farnesoid X receptor (FXR) is an endogenous sensor for bile acids and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene expression. The aim of thisExpand
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Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis
The nuclear receptors farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)γ exert counter-regulatory effects on hepatic stellate cells (HSCs) and protect against liverExpand
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  • Open Access
A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes
The farnesoid X receptor (FXR) is expressed by and regulates hepatic stellate cells (HSCs). In the present study, we investigated whether 6-ethyl chenodeoxycholic acid (6-ECDCA or INT-747), aExpand
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  • Open Access
Thrombospondin‐1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice
The function of the endogenous angiogenesis inhibitor thrombospondin‐1 (TSP‐1) in tissue repair has remained controversial. We established transgenic mice with targeted overexpression of TSP‐1 in theExpand
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Melatonin modulates signal transduction pathways and apoptosis in experimental colitis
Abstract:  Various evidences have documented that the pineal secretory product melatonin exerts an important anti‐inflammatory effect in different experimental models including colitis. The aim ofExpand
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Effects of verbascoside biotechnologically produced by Syringa vulgaris plant cell cultures in a rodent model of colitis
The aim of the present study was to examine the effects of verbascoside (VB) in rats subjected to experimental colitis. Colitis was induced in rats by intracolonic instillation of 2,4 dinitrobenzeneExpand
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GITR Gene Deletion and GITR-Fc Soluble Protein Administration Inhibit Multiple Organ Failure Induced by Zymosan
Multiple organ dysfunction syndrome (MODS) is a systemic inflammatory event that can result in organ damage, failure, and high risk of mortality. The aim of this study was to evaluate the possibleExpand
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Matrix metalloproteinase‐9 and metalloproteinase‐2 activity and expression is reduced by melatonin during experimental colitis
Abstract:  Matrix metalloproteinases (MMPs) are associated with matrix turnover in both physiological and pathological conditions. Several data indicate that MMPs play an important role in theExpand
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-&agr; MODULATES THE ANTI-INFLAMMATORY EFFECT OF GLUCOCORTICOIDS IN A MODEL OF INFLAMMATORY BOWEL DISEASE IN MICE
Glucocorticoids (GCs) are effective anti-inflammatory agents widely used in therapeutic approach to treatment of inflammatory bowel disease (IBD). Previous results suggest that peroxisomeExpand
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The glucocorticoid‐induced TNF receptor family‐related protein (GITR) is critical to the development of acute pancreatitis in mice
BACKGROUND AND PURPOSE Pancreatitis represents a life‐threatening inflammatory condition where leucocytes, cytokines and vascular endothelium contribute to the development of the inflammatoryExpand
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