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Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
- Ashley J Fowler, M. Sheu, +8 authors K. Feingold
- Biology, MedicineThe Journal of investigative dermatology
- 1 February 2003
It is demonstrated that activators of LXR display potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRalpha and LXRbeta, and could provide a new class of therapeutic agents for the treatment of cutaneous inflammatory disorders.
Surfactant structure effects on swelling of isolated human stratum corneum
In Vitro Interactions: Biochemical and Biophysical Effects of Surfactants on Skin
- L. Rhein
Stratum corneum lipid removal by surfactants: relation to in vivo irritation.
These findings challenge earlier assumptions that surfactants' degreasing of the SC is involved in the induction of erythema and suggest that the milder forms of irritation--dryness, tightness, roughness--may involve both surfactant binding to and denaturation of keratin as well as disruption of lipid.
Surfactants in Personal Care Products and Decorative Cosmetics
Part I ASSESSMENT OF PERSONAL CARE AND DECORATIVE COSMETICS Review of Skin Structure and Function with Special Focus on Stratum Corneum Lipid L.D. Rhein and S. Babajanyan Color Measurement Techniques…
Sequential order of skin responses to surfactants during the soap chamber test
This study indicates that for discriminating among mild products, when a small degree of irritation is induced, the most effective measure is stratum corneum damage assessed by evaporimetry, however, for evaluating more irritating products, erythema is probably the more discriminating evaluation technique.
Biochemical Studies of Olfaction: Binding Specificity of Odorants to a Cilia Preparation from Rainbow Trout Olfactory Rosettes
Cilia isolated from the olfactory epithelium of rainbow trout bind amino acids, which are odor stimuli to this species, to demonstrate that L‐threonine, l‐serine, and l‐alanine bind to a common site, TSA, in the cilia preparation.
Human cutaneous response to a mixed surfactant system: role of solution phenomena in controlling surfactant irritation.
- L. Rhein, F. Simion, R. Hill, R. H. Cagan, J. Mattai, H. Maibach
- Chemistry, MedicineDermatologica
Results demonstrate that addition of AEOS-7EO to a constant dose of SLS results in a significant reduction in erythema, hence producing a milder system.
Quantitation of erythema in a soap chamber test using the Minolta Chroma (Reflectance) Meter: Comparison of instrumental results with visual assessments
Self-perceived sensory responses to soap and synthetic detergent bars correlate with clinical signs of irritation.
- F. Simion, L. Rhein, +4 authors G. Grove
- MedicineJournal of the American Academy of Dermatology
- 1 February 1995
Sensory evaluations of irritation yield additional information on soap and detergent irritancy beyond clinical observations and expand understanding of the irritation process.