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Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain*
Huntington disease is a devastating neurodegenerative disease caused by the expansion of a polymorphic glutamine tract in huntingtin. The huntingtin interacting protein (HIP-1) was identified by itsExpand
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Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease
Huntington disease (HD) is a neurodegenerative disorder caused by an expanded CAG tract in the HD gene. Polyglutamine expansion of huntingtin (htt) results in early, progressive loss of medium spinyExpand
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Identification of sterol acceptors that stimulate cholesterol efflux from human spermatozoa during in vitro capacitation.
The nature of cholesterol-binding proteins acting upon human spermatozoa during in vitro capacitation was determined by measuring the efflux of [3H]cholesterol and of [3H]cholesteryl sulfate fromExpand
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Mechanisms of amiloride stimulation of Mg2+ uptake in immortalized mouse distal convoluted tubule cells.
The distal convoluted tubule reabsorbs approximately 10% of the filtered magnesium, which is approximately 70% of that delivered to it from the loop of Henle. The cellular mechanisms of magnesiumExpand
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Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase
Alzheimer's disease (AD) is a disorder of two pathologies: amyloid plaques, the core of which is a peptide derived from the amyloid precursor protein (APP), and neurofibrillary tangles composed ofExpand
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Progranulin Deficiency Decreases Gross Neural Connectivity But Enhances Transmission at Individual Synapses
Frontotemporal dementia (FTD) has been linked to mutations in the progranulin gene (GRN) that lead to progranulin (PGRN) haploinsufficiency. Thus far, our understanding of the effects of PGRNExpand
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Channels formed by colicin E1 in planar lipid bilayers are large and exhibit pH-dependent ion selectivity
SummaryThe E1 subgroup (E1, A, Ib, etc.) of antibacterial toxins called colicins are known to form voltage-dependent channels in planar lipid bilayers. The genes for colicins E1, A and Ib have beenExpand
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Na+/Ca2+ exchanger in epithelial cells of the porcine cortical thick ascending limb.
Intracellular Ca2+ concentration ([Ca2+]i) plays an important role in the signal transduction processes within cortical thick ascending limb (CTAL) cells. Control of [Ca2+]i was investigated inExpand
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Gating of a voltage-dependent channel (colicin E1) in planar lipid bilayers: the role of protein translocation
SummaryThe voltage-dependent channel formed in planar lipid bilayers by colicin E1, or its channel-forming C-terminal fragments, is susceptible to destruction by the nonspecific protease pepsin underExpand
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Primary CD30-positive anaplastic large cell lymphoma of the lip.
We report a case of primary CD30-positive anaplastic large cell lymphoma of the lip. While extranodal involvement is not uncommon in Ki-1(CD30) anaplastic large cell lymphoma, this is the firstExpand
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