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Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling.
UNLABELLED Rodent models and genetically altered mice have recently become available to study many human diseases. A sensitive and accurate PET scanner for small animals would be useful to evaluateExpand
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Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation.
Paclitaxel (Taxol) is a clinically important chemotherapeutic agent. We describe the synthesis of fluoro-, bromo-, and iodopaclitaxel and their [(18)F]fluoro-, [(76)Br]bromo-, and [(124)I]iodo-Expand
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Anatomical and biochemical investigation of primary brain tumours
Cancerous transformation entails major biochemical changes including modifications of the energy metabolism of the cell, e.g. utilisation of glucose and other substrates, protein synthesis, andExpand
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GABAA receptor abnormalities in Prader–Willi syndrome assessed with positron emission tomography and [11C]flumazenil
We used positron emission tomography of the benzodiazepine binding site employing [11C]flumazenil to assess cerebral GABA(A) receptors in Prader-Willi syndrome and found a reduction in the binding site of the receptor in the cingulate, frontal and temporal neocortices and insula. Expand
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Operational lumped constant for FDG in normal adult male rats.
UNLABELLED We determined an operational value for the lumped constant to be used in measurements of the local rate of cerebral glucose use (lCMR(glc)) with FDG in normal adult male rats. METHODSExpand
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Calculation of electron dose to target cells in a complex environment by Monte Carlo code “CELLDOSE”
BackgroundWe used the Monte Carlo code “CELLDOSE” to assess the dose received by specific target cells from electron emissions in a complex environment. 131I in a simulated thyroid was used as aExpand
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Role of [18F]FDG-PET/CT after radiofrequency ablation of liver metastases: preliminary results
PurposeFocal metastasis may be treated with radiofrequency ablation (RFA), a low invasive method yet limited by the lack of direct evidence of radicality of treatment. We, hereby, aimed at assessingExpand
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Circulating levels of VCAM and MMP-2 may help identify patients with more aggressive prostate cancer.
BACKGROUND Prostate adenocarcinoma is generally characterized by slow progression although some phenotypes have a more aggressive behavior with tendency to local invasion and distant metastases,Expand
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Intraoperative Avidination for Radionuclide Therapy: A Prospective New Development to Accelerate Radiotherapy in Breast Cancer
Purpose: In a continuous effort to seek for anticancer treatments with minimal side effects, we aim at proving the feasibility of the Intraoperative Avidination for Radionuclide Therapy, a newExpand
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Evaluation of [76Br]FBAU 3',5'-dibenzoate as a lipophilic prodrug for brain imaging.
[76Br]FBAU is a potential PET tracer for assessing proliferation. This study proposes that [76Br]FBAU 3',5'-dibenzoate has higher blood-brain-barrier permeability than [76Br]FBAU itself and thusExpand
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