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Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa
The out-of-Africa scenario has hitherto provided little evidence for the precise route by which modern humans left Africa. Two major routes of dispersal have been hypothesized: one through NorthExpand
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TLR3 Deficiency in Patients with Herpes Simplex Encephalitis
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report aExpand
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Where west meets east: the complex mtDNA landscape of the southwest and Central Asian corridor.
The southwestern and Central Asian corridor has played a pivotal role in the history of humankind, witnessing numerous waves of migration of different peoples at different times. To evaluate theExpand
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Natural selection has driven population differentiation in modern humans
The considerable range of observed phenotypic variation in human populations may reflect, in part, distinctive processes of natural selection and adaptation to variable environmental conditions.Expand
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Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes,Expand
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The dawn of human matrilineal diversity.
The quest to explain demographic history during the early part of human evolution has been limited because of the scarce paleoanthropological record from the Middle Stone Age. To shed light on theExpand
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Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females
Examining Y The evolution of human populations has long been studied with unique sequences from the nonrecombining, male-specific Y chromosome (see the Perspective by Cann). Poznik et al. (p. 562)Expand
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Autoantibodies against type I IFNs in patients with life-threatening COVID-19
The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNsExpand
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The Genetic Legacy of Religious Diversity and Intolerance: Paternal Lineages of Christians, Jews, and Muslims in the Iberian Peninsula
Most studies of European genetic diversity have focused on large-scale variation and interpretations based on events in prehistory, but migrations and invasions in historical times could also haveExpand
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Y-chromosome lineages trace diffusion of people and languages in southwestern Asia.
The origins and dispersal of farming and pastoral nomadism in southwestern Asia are complex, and there is controversy about whether they were associated with cultural transmission or demic diffusion.Expand
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