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Autoantibodies against type I IFNs in patients with life-threatening COVID-19
TLDR
A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.
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Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa
TLDR
M is rendered the first genetic indicator for the hypothesized exit route from Africa through eastern Africa/western India, possibly the only successful early dispersal event of modern humans out of Africa.
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TLR3 Deficiency in Patients with Herpes Simplex Encephalitis
TLDR
Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance ofTLR3.
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Where west meets east: the complex mtDNA landscape of the southwest and Central Asian corridor.
TLDR
A number of deep-rooting lineages, whose relative clustering and coalescent ages suggest an autochthonous origin in the southwestern Asian corridor during the Pleistocene are observed.
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Natural selection has driven population differentiation in modern humans
TLDR
The degree of population differentiation is analyzed at 2.8 million Phase II HapMap single-nucleotide polymorphisms to identify a fraction of loci that have contributed, and probably still contribute, to the morphological and disease-related phenotypic diversity of current human populations.
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Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
TLDR
It is found that the intracellular TLRs—activated by nucleic acids and particularly specialized in viral recognition—have evolved under strong purifying selection, indicating their essential non-redundant role in host survival.
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The dawn of human matrilineal diversity.
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The Genetic Legacy of Religious Diversity and Intolerance: Paternal Lineages of Christians, Jews, and Muslims in the Iberian Peninsula
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From evolutionary genetics to human immunology: how selection shapes host defence genes
TLDR
Findings from population genetic studies are helping to delineate genes that are important for host defence and to increase the understanding of how past selection has had an impact on disease susceptibility in modern populations.
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Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females
TLDR
The findings suggest that, contrary to previous claims, male lineages do not coalesce significantly more recently than female lineages.
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