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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
Inflammation is implicated in the progressive nature of neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are poorly understood. A single systemic lipopolysaccharide (LPS, 5Expand
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NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia*
  • L. Qin, Y. Liu, +5 authors J. Hong
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 9 January 2004
Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra. We have previously reported that lipopolysaccharide (LPS)-induced degeneration ofExpand
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Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
BackgroundCytokines and alcohol share a common modulation of inflammation and hormones as well as being implicated in multiple diseases, but the mechanisms are poorly understood. The purpose of thisExpand
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Cytokines and alcohol.
Cytokines are multifunctional proteins that play a critical role in cellular communication and activation. Cytokines have been classified as being proinflammatory (T helper 1, Th1) orExpand
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Induction of innate immune genes in brain create the neurobiology of addiction
Addiction occurs through repeated abuse of drugs that progressively reduce behavioral control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries indicateExpand
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NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
  • L. Qin, F. Crews
  • Medicine, Biology
  • Journal of Neuroinflammation
  • 12 January 2012
BackgroundActivation of microglia causes the production of proinflammatory factors and upregulation of NADPH oxidase (NOX) that form reactive oxygen species (ROS) that lead to neurodegeneration.Expand
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Role of reactive oxygen species in LPS‐induced production of prostaglandin E2 in microglia
We determined the roles of reactive oxygen species (ROS) in the expression of cyclooxygenase‐2 (COX‐2) and the production of prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)‐activated microglia.Expand
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Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
The contributing role of environmental factors to the development of Parkinson’s disease has become increasingly evident. We report that mesencephalic neuron‐glia cultures treated with diesel exhaustExpand
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BHT blocks NF-κB activation and ethanol-induced brain damage
Background: Binge ethanol administration causes corticolimbic brain damage that models alcoholic neurodegeneration. The mechanism of binge ethanol-induced degeneration is unknown, but is not simpleExpand
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High Mobility Group Box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in Alcohol Dependence
BACKGROUND Innate immune gene expression is regulated in part through high mobility group box 1 (HMGB1), an endogenous proinflammatory cytokine, that activates multiple members of theExpand
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