• Publications
  • Influence
Dishevelled promotes axon differentiation by regulating atypical protein kinase C
The atypical protein kinase C (aPKC) in complex with PAR3 and PAR6 is required for axon-dendrite differentiation, but the upstream factors responsible for regulating its activity are largely unknown.Expand
  • 195
  • 11
  • PDF
Wnt/β-Catenin Signaling Suppresses Rapsyn Expression and Inhibits Acetylcholine Receptor Clustering at the Neuromuscular Junction*
The dynamic interaction between positive and negative signals is necessary for remodeling of postsynaptic structures at the neuromuscular junction. Here we report that Wnt3a negatively regulatesExpand
  • 71
  • 7
  • PDF
Visfatin inhibits apoptosis of pancreatic β-cell line, MIN6, via the mitogen-activated protein kinase/phosphoinositide 3-kinase pathway.
Visfatin is an adipocytokine that plays an important role in attenuating insulin resistance by binding to insulin receptor. It has been suggested that visfatin plays a role in the regulation of cellExpand
  • 61
  • 5
  • PDF
Rapsyn Interaction with Calpain Stabilizes AChR Clusters at the Neuromuscular Junction
Agrin induces, whereas acetylcholine (ACh) disperses, ACh receptor (AChR) clusters during neuromuscular synaptogenesis. Such counteractive interaction leads to eventual dispersal of nonsynapticExpand
  • 89
  • 5
  • PDF
Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
The mammalian nicotinamide‐adenine dinucleotide (NAD)‐dependent deacetylase Sirt1 impacts different processes involved in the maintenance of brain integrity and in the pathogenic pathways associatedExpand
  • 101
  • 3
Palmitate activates AMP-activated protein kinase and regulates insulin secretion from beta cells.
AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular metabolism. Changes in AMPK activity contribute to the regulation of insulin secretion. Epidemiological evidence linksExpand
  • 42
  • 3
Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and high-cholesterol diets.
AIMS Obesity is associated with hypertriglyceridemia and elevated circulating free fatty acids (FFA), resulting in endothelial dysfunction. Endoplasmic reticulum (ER) stress has been implicated inExpand
  • 39
  • 2
Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells.
Changes in AMP-activated protein kinase (AMPK) activity contribute to the regulation of insulin secretion. Troglitazone has been shown to lower serum insulin levels and protect beta cell function.Expand
  • 29
  • 2
Astragaloside IV attenuates lipolysis and improves insulin resistance induced by TNFα in 3T3‐L1 adipocytes
Increased circulating free fatty acid (FFA) concentrations have been demonstrated to potentially link obesity, insulin resistance and cardiovascular diseases. Astragaloside IV (AS‐IV) is a saponinExpand
  • 30
  • 1
Protective effects of hydroxysafflor yellow an on high oxidized low density lipoprotein induced human coronary artery endothelial cells injuries
The aim of this study was to investigate the injury of human coronary artery endothelial cells (HCAECs) induced by high oxidized low density lipoprotein (ox-LDL) and to examine the protective effectExpand
  • 2
  • 1
  • PDF