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The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability.
In a study involving four raters and 40 patients with obsessive-compulsive disorder at various stages of treatment, interrater reliability for the total Yale-Brown Scale score and each of the 10 individual items was excellent, with high degree of internal consistency among all item scores demonstrated with Cronbach's alpha coefficient. Expand
The Yale-Brown Obsessive Compulsive Scale. II. Validity.
Results from a previously reported placebo-controlled trial of fluvoxamine in 42 patients with obsessive-compulsive disorder showed that the Yale- Brown Scale was sensitive to drug-induced changes and that reductions in Yale-Brown Scale scores specifically reflected improvement in obsessive- compulsive disorder symptoms. Expand
Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.
The behavioral effects of rapid tryptophan depletion in patients in antidepressant-induced remission and the therapeutic effects of some antidepressant drugs may be dependent on serotonin availability are investigated. Expand
Family accommodation in obsessive-compulsive disorder.
Family accommodation of patients with obsessive-compulsive disorder was associated with global family dysfunction and stress and it is suggested that families' efforts to accommodate patients may be intended to reduce patient anxiety or anger directed at relatives. Expand
Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor. Expand
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Data suggest that TRP depletion results in substantial declines in central 5-HT turnover, which is similar to that observed in healthy adult subjects after a one-day low-TRP diet and a TRP-free amino acid drink. Expand
Yale Brown Obsessive Compulsive Scale
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
Deep brain stimulation of the VC/VS offers promise for the treatment of refractory major depression. Expand
Family accommodation of obsessive-compulsive symptoms: instrument development and assessment of family behavior.
The Family Accommodation Scale for Obsessive-Compulsive Disorder (FAS) will provide researchers and clinicians with a useful tool for assessing family accommodation and for identifying families who may benefit from interventions aimed at developing more adaptive coping strategies. Expand
Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
This rating scale is designed to rate the severity and type of symptoms in patients with obsessive compulsive disorder (OCD). In general, the items depend on the patient's report; however, the finalExpand