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Understanding the central role of citrate in the metabolism of cancer cells.
Cancers cells strongly stimulate glycolysis and glutaminolysis for their biosynthesis. Pyruvate derived from glucose is preferentially diverted towards the production of lactic acid (Warburg effect).… Expand
Resistance of colon cancer cells to long‐term 5‐fluorouracil exposure is correlated to the relative level of Bcl‐2 and Bcl‐XL in addition to Bax and p53 status
- S. Violette, L. Poulain, +6 authors T. Lesuffleur
- Medicine, Biology
- International journal of cancer
- 1 April 2002
Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell lines differing in… Expand
Downregulation of Bcl-xL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy.
Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis and limited response to platinum-based chemotherapy. Several lines of evidence support a role for the anti-apoptotic… Expand
Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering.
Cartilage engineering is one of the most challenging issue in regenerative medicine, due to its limited self-ability to repair. Here, we assessed engineering of cartilage tissue starting from human… Expand
miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation
- C. Denoyelle, B. Lambert, +9 authors L. Poulain
- Biology, Medicine
- Cell Death and Disease
- 1 October 2014
We sought to identify miRNAs that can efficiently induce apoptosis in ovarian cancer cells by overcoming BCL-XL and MCL1 anti-apoptotic activity, using combined computational and experimental… Expand
Effect of citrate on malignant pleural mesothelioma cells: a synergistic effect with cisplatin.
- Xiaodong Zhang, E. Varin, S. Allouche, Y. Lu, L. Poulain, P. Icard
- Anticancer research
- 1 April 2009
BACKGROUND Because cancer cells are partly or mainly dependent on glycolysis to generate ATP (Warburg effect), any inhibition of glycolysis may slow down their proliferation or kill them. MATERIALS… Expand
Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to…
- M. Villedieu, E. Deslandes, M. Duval, J-F Héron, P. Gauduchon, L. Poulain
- Gynecologic oncology
- 1 June 2006
OBJECTIVE Recurrence and cisplatin resistance that progressively develops in the course of treatments are major impediments in ovarian cancer therapy. We investigated the involvement of alterations… Expand
PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced.
We previously showed that Bcl-xL and Mcl-1 cooperatively protect platinum-resistant ovarian cancer cells from apoptosis. Here we assessed the anticancer potential of combining ABT-737-induced… Expand
Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro.
BACKGROUND 2-Deoxy-D-glucose (2-DG) is an analog of glucose that is preferentially captured by tumors and is accumulated in transformed cells, because the phosphorylated molecule (2-DG-6P) cannot be… Expand
Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells
- Karin Simonin, É. Brotin, +6 authors L. Poulain
- Medicine, Biology
- Molecular Cancer Therapeutics
- 1 November 2009
Chemoresistance of ovarian carcinoma has been associated previously to the absence of Bcl-xL expression downregulation in response to cisplatin. Among BH3-mimetic molecules constituting promising… Expand