A Small, Stable RNA Induced by Oxidative Stress: Role as a Pleiotropic Regulator and Antimutator
- S. Altuvia, Dalit Weinstein-Fischer, A. Zhang, L. Postow, G. Storz
- BiologyCell
- 11 July 1997
Topological domain structure of the Escherichia coli chromosome.
- L. Postow, Christine D Hardy, J. Arsuaga, N. Cozzarelli
- BiologyGenes & Development
- 15 July 2004
It is concluded that domain barriers are not placed stably at fixed sites on the chromosome but instead are effectively randomly distributed, and that domains are much smaller than previously reported, approximately 10 kb on average.
Ku80 removal from DNA through double strand break–induced ubiquitylation
- L. Postow, Cristina Ghenoiu, Eileen M. Woo, A. Krutchinsky, B. Chait, H. Funabiki
- BiologyJournal of Cell Biology
- 11 August 2008
This work demonstrates that DSB-induced ubiquitylation of Ku80 is degraded in response to DSBs in a ubiquitin-mediated manner and proposed mechanism to efficiently eliminate Ku from DNA for pre- and postrepair processes.
Identification of SMARCAL1 as a Component of the DNA Damage Response*
- L. Postow, Eileen M. Woo, B. Chait, H. Funabiki
- BiologyJournal of Biological Chemistry
- 19 October 2009
It is proposed that SMARCAL1 is a novel DNA damage-binding protein involved in replication fork stabilization and depletion of SMARCal1 from U2OS cells leads to increased frequency of RAD51 foci upon generation of stalled replication forks.
An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation
- L. Postow, H. Funabiki
- Biology, ChemistryCell Cycle
- 16 January 2013
It is shown that the Skp1-Cul1-F box (SCF) E3 ubiquitin ligase complex is required for Ku80 ubiquitylation and removal from DNA.
Topological challenges to DNA replication: Conformations at the fork
- L. Postow, N. J. Crisona, B. Peter, Christine D Hardy, N. Cozzarelli
- BiologyProceedings of the National Academy of Sciences…
- 17 July 2001
The importance of replicating DNA conformations and the roles of topoisomerases are discussed, focusing on recent work from the laboratory.
Positive Torsional Strain Causes the Formation of a Four-way Junction at Replication Forks*
- L. Postow, C. Ullsperger, R. Keller, C. Bustamante, A. Vologodskii, N. Cozzarelli
- BiologyJournal of Biological Chemistry
- 26 January 2001
It is shown by restriction endonuclease digestion that the junction can form at either the terminus or the origin of replication and the structure is visualized with scanning force microscopy and discussed possible physiological implications of the junction for stalled replication in vivo.
NIH electronic cigarette workshop: developing a research agenda.
- Kevin M. Walton, D. Abrams, D. Hatsukami
- MedicineNicotine & Tobacco Research
- 1 February 2015
This paper describes proceedings from a National Institutes of Health-sponsored workshop, which was held in November 2013, to identify research needs related to the effects of e-cigarettes, and identifies the research needs identified by participants.
Chronic Obstructive Pulmonary Disease and Smoking Status — United States, 2017
- A. Wheaton, Yong Liu, K. Greenlund
- Medicine, PsychologyMMWR. Morbidity and mortality weekly report
- 21 June 2019
A similar relationship among adults who had never smoked suggests secondhand smoke exposure as a potential risk factor for COPD, and continued promotion of smoke-free environments might reduce COPD among both those who smoke and those who do not.
...
...