L. Possani

Publications474
h-index63
Citations14,707
Highly Influential Citations423
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Scorpion toxins specific for Na+-channels.
TLDR
A classification containing 10 different groups of toxins is proposed in this review, based on functional and structural features of the known toxins, and the limited success obtained in the search for the site through which these peptides bind to the channels. Expand
Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones)
TLDR
This report contains the first transcriptome analysis of genes transcribed by the venomous gland of a scorpion, and provides the first sketch of cellular components, molecular functions, biological processes and some unique sequences of the scorpion venom gland. Expand
Current views on scorpion toxins specific for K+-channels.
TLDR
The evolutionary tree indicates that several clusters of divergent peptides show preference for specific subtypes of channels, and four different interacting modes were identified to exist between scorpion toxins and the various sub types of K+-channels. Expand
Peptides and genes coding for scorpion toxins that affect ion-channels.
TLDR
The entire repertoire of toxins, independently of their specificity, was analyzed together by computational programs and a phylogenetic tree was built showing two separate branches, showing clear similarities among them. Expand
Scorpion venom components as potential candidates for drug development
TLDR
This review summarizes the most promising candidates for drug development that have been isolated from scorpion venoms with the potential to tackle many of the emerging global medical threats. Expand
Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus.
TLDR
These three species of scorpion have similar toxic components, the genes of which are similarly organized, processed and expressed, and are consequently named gamma-b and gamma-st respectively. Expand
Mapping the Binding Site of a Humanether-a-go-go-related Gene-specific Peptide Toxin (ErgTx) to the Channel's Outer Vestibule*
TLDR
This study proposes that the long S5-P linker of the HERG channel forms an amphipathic α-helix that, together with the P-S6 linker, forms a hydrophobic ErgTx binding site, which paves the way for future mutant cycle analysis of interacting residues in the Ergtx·HERG complex, which will yield information about the topology of HERG's outer vestibule. Expand
Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing.
TLDR
The results strongly support the conclusion that C. exilicauda and C. sculpturatus are in fact two distinct species of scorpions. Expand
Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus.
TLDR
A novel toxin isolated from the venom of the scorpion Androctonus mauretanicus was isolated and patch-clamp experiments on striatal neurons in culture demonstrated that AmmTX3 was able to inhibit the A-type K+ current. Expand
Scorpionism and serotherapy in Mexico.
TLDR
My personal experience in treating 38,068 people, from which over 20,000 received serotherapy, shows that the antiserum is very effective, in that none of the patients died. Expand
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