• Publications
  • Influence
Prolyl Oligopeptidase An Unusual β-Propeller Domain Regulates Proteolysis
TLDR
A resolution crystal structure of prolyl oligopeptidase, a large cytosolic enzyme that belongs to a new class of serine peptidases, is presented, which may facilitate drug design to treat memory disorders. Expand
The prolyl oligopeptidase family
  • L. Polgár
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 1 February 2002
TLDR
The recent crystal structure determination of prolyl oligopeptidase has shown that the enzyme contains a peptidase domain with an α/β hydrolase fold, and its catalytic triad is covered by the central tunnel of an unusual seven-bladed β-propeller, excluding large, structured peptides from the active site. Expand
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.
TLDR
The structure of prolyl oligopeptidase is obtained with a transition state inhibitor, which may facilitate drug design to treat memory disorders and protect larger peptides and proteins from proteolysis in the cytosol. Expand
Results of the seventh joint pesticide testing programme carried out by the IOBC/WPRS-Working Group ‘Pesticides and Beneficial Organisms’
The side effect of 10 insecticides, 5 fungicides and 5 herbicides on 24 different species of beneficial organisms was tested by members of the Working Group ‘Pesticides and Beneficial Organisms’ ofExpand
Results of the sixth joint pesticide testing programme of the IOBC/WPRS-working group «pesticides and beneficial organisms»
The side effects of 5 insecticides, 8 fungicides and 6 herbicides on 24 species of beneficial organisms were tested by members of the Working Group «Pesticides and Beneficial Organisms» of theExpand
The catalytic triad of serine peptidases
  • L. Polgár
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 7 July 2005
TLDR
Several new families have been discovered, in which the nucleophile-base-acid pattern is generally conserved, but the individual components can vary, illustrating how different groups and different protein structures achieve the same reaction. Expand
How can the mood stabilizer VPA limit both mania and depression?
TLDR
It is reported that VPA directly inhibits recombinant PO activity, which would have the opposite effect on PIns signaling, and this unexpected result suggests a model that could explain the dual action of VPA in stabilizing mood. Expand
Mechanisms of Protease Action
The Chemistry of the Peptide Bond. General Aspects of Proteases. Serine Proteases. Cysteine Proteases. Aspartic Proteases. Metalloproteases. Index.
Results of the fifth joint pesticide testing programme carried out by the IOBC/WPRS-Working Group “Pesticides and beneficial organisms”
TLDR
The activities of the working group to complete the development of urgently needed sequential procedure to test the side effects of pesticides on beneficial organisms based on standard laboratory, semi field and field methods and the need for more international cooperation are discussed. Expand
pH-dependent mechanism in the catalysis of prolyl endopeptidase from pig muscle.
  • L. Polgár
  • Chemistry, Medicine
  • European journal of biochemistry
  • 1 April 1991
TLDR
It is concluded that a general base/acid-catalyzed acylated step is rate-limiting in the lower pH range, and an isotopically silent step, probably a conformational change preceding acylation, dominates the reaction in the physiological pH range. Expand
...
1
2
3
4
5
...