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Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Oligodendroglia metabolically support axons and contribute to neurodegeneration
It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
Activity‐dependent regulation of energy metabolism by astrocytes: An update
Very recent experimental evidence as well as theoretical arguments strongly supporting the original astrocyte‐neuron lactate shuttle concept are reviewed, with new perspectives offered by the application of this concept.
Monocarboxylate transporters in the central nervous system: distribution, regulation and function
New data indicate that MCT expression is regulated at the translational level by neurotransmitters, suggesting a particular role of monocarboxylates and their transporters in synaptic transmission.
The selfish brain: competition for energy resources
Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle
Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to maintain synaptic transmission,…
Comparison of Lactate Transport in Astroglial Cells and Monocarboxylate Transporter 1 (MCT 1) Expressing Xenopus laevis Oocytes
Comparison of lactate transport in MCT1 expressing oocytes with lactate Transport in glial cells revealed that MCT 1 can account for all characteristics of lactates transport inglial cells, providing further molecular support for the existence of a lactate shuttle between astrocytes and neurons.
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.
- P. Magistretti, L. Pellerin
- Biology, ChemistryPhilosophical transactions of the Royal Society…
- 29 July 1999
The proposed model provides a direct mechanism to couple synaptic activity with glucose use and is consistent with the notion that the signals detected during physiological activation with 18F-deoxyglucose (DG)-PET may reflect predominantly uptake of the tracer into astrocytes.
Sweet Sixteen for ANLS
The ANLS model now represents a useful, experimentally based framework to better understand the coupling between neuronal activity and energetics as it relates to neuronal plasticity, neurodegeneration, and functional brain imaging.
Selective Distribution of Lactate Dehydrogenase Isoenzymes in Neurons and Astrocytes of Human Brain
- P. Bittar, Y. Charnay, L. Pellerin, C. Bouras, P. Magistretti
- BiologyJournal of cerebral blood flow and metabolism…
- 1 November 1996
In vivo data suggest that lactate may be formed in certain cells and oxidized in others, and the production and characterization of two rat antisera, specific for the LDH-5 andLDH-1 subunits of lactate dehydrogenase, respectively support the notion of a regulated lactate flux between astrocytes and neurons.