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Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer
- S. Greenall, J. Bentley, +7 authors T. Adams
- Biology, Medicine
- The Journal of Biological Chemistry
- 19 November 2012
IGF-II isoforms possess unique biological properties that may enable them to escape normal sequestration avenues and remain bioavailable in vivo to sustain oncogenic signaling. Expand
Single-chain Fv fragments of anti-neuraminidase antibody NC10 containing five- and ten-residue linkers form dimers and with zero-residue linker a trimer.
BIAcore biosensor experiments showed that when the scFvs were used as the analyte, the dimeric and trimeric scFVS showed an apparent increase in binding affinity due to the avidity of binding the multivalent scFv. Expand
Kinetic screening of antibody-Im7 conjugates by capture on a colicin E7 DNase domain using optical biosensors.
The high-affinity interaction between the naturally occurring nuclease domain of E. coli colicin E7 and its cognate partner, the immunity protein 7 (Im7), is exploited to develop a ligand capture system suitable for accurate kinetic ranking of library clones. Expand
Structural studies of the tethered N‐terminus of the Alzheimer's disease amyloid‐β peptide
This novel structure has the potential to provide a foundation for investigating the effect of metal ion binding to Aβ and illustrates a potential target for the development of future Alzheimer's disease therapeutics aimed at stabilizing the N‐terminal monomer structure, in particular residues His13 and His14. Expand
ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in V(L) to V(H) orientation drives the formation of dimers, trimers, tetramers…
- O. Dolezal, L. Pearce, L. Lawrence, A. McCoy, P. Hudson, A. Kortt
- Chemistry, Medicine
- Protein engineering
- 1 August 2000
Analysis of synthetic genes encoding single-chain variable fragments of NC10 anti-neuraminidase antibody showed that as the linker length between V(L) and V(H) was reduced, different patterns of oligomerization were observed, and the transition between dimers and higher order oligomers was not as distinct as for V (H)-V(L). Expand
Progressive myoclonus epilepsy with Lafora inclusion bodies. II. Studies of ultrastructure.
The ultrastructure of the inclusion bodies found in cerebral cortical biopsy specimens from two patients with Lafora's disease are described, and the ultrast structure of liver and gastrocnemius muscle are briefly described. Expand
Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment
- R. Robert, V. Streltsov, J. Newman, L. Pearce, K. Wark, O. Dolezal
- Biology, Medicine
- Protein science : a publication of the Protein…
- 1 February 2010
The humanization of WO‐2 is described using complementary determining region loop grafting onto the human germline gene and the determination of the three‐dimensional structure by X‐ray crystallography, which indicates this humanized version retains a high affinity for the Aβ peptide and therefore is a potential candidate for passive immunotherapy of Alzheimer's disease. Expand
Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma.
The superior in vitro and in vivo anti-tumor activity of panitumumab support further clinical testing of this antibody against EGFRvIII-stratified glioma. Expand
FAMILIAL HYPOKALEMIC PERIODIC PARALYSIS WITH PERMANENT MYOPATHY A CLINICAL AND ULTRASTBCCTURAL STUDY
A patient with familial hypokalemic periodic paralysis associated with permanent weakness and wasting of the limb musculature proximally is evaluated, and some of the clinical and ultrastructural findings differ from those previously recorded. Expand
Familial spinocerebellar degeneration, hemolytic anemia, and glutathione deficiency.
- F. Richards, M. Cooper, L. Pearce, R. Cowan, C. Spurr
- Archives of internal medicine
- 1 September 1974
Preliminary studies indicate that this may be the only reported family with GSH deficiency due to γglutamyl-cysteine synthetase deficiency, and patients with autosomal recessive forms of spinocerebellar degeneration should be examined for disorders of GSH synthesis. Expand