The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.
- L. Passmore, T. Schmeing, V. Ramakrishnan
- Biology, ChemistryMolecules and Cells
- 13 April 2007
Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition
- L. Passmore, E. A. McCormack, D. Barford
- BiologyEMBO Journal
- 17 February 2003
It is shown that both the D and KEN boxes contribute to substrate recognition and that coactivator is required for substrate binding, implying that Doc1p/Apc10 may play a role to regulate the binding of specific substrates, similar to that of the coactivators.
mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases
- M. W. Webster, Ying-Hsin Chen, L. Passmore
- BiologyMolecules and Cells
- 1 June 2018
Getting into position: the catalytic mechanisms of protein ubiquitylation.
- L. Passmore, D. Barford
- Biology, ChemistryBiochemical Journal
- 1 May 2004
The complexity of molecular recognition required to impose selectivity on substrate selection and topology of poly-ubiquitin chains is discussed, including the mechanisms of E1, E2 and E3.
Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging
- T. Bharat, C. Russo, J. Löwe, L. Passmore, S. Scheres
- GeologyStructure
- 1 September 2015
The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
- E. Rajendra, V. Oestergaard, L. Passmore
- BiologyMolecules and Cells
- 5 June 2014
Ultrastable gold substrates for electron cryomicroscopy
- C. Russo, L. Passmore
- BiologyScience
- 12 December 2014
A gold specimen support is demonstrated that nearly eliminates substrate motion during irradiation and determines the structure of apoferritin, a smooth octahedral shell of α-helical subunits that is particularly difficult to solve by electron microscopy.
Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain
- C. Tognon, H. Kirk, L. Passmore, I. Whitehead, C. Der, R. Kay
- Biology, Computer ScienceMolecular and Cellular Biology
- 1 December 1998
The results suggest that the primary mechanism of activation of mRasGRP in fibroblasts is through its recruitment to diacylglycerol-enriched membranes.
Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation
- J. Wolf, E. Valkov, L. Passmore
- BiologyEMBO Journal
- 29 May 2014
It is shown that Pan3 binds RNA directly both through its pseudokinase/C‐ terminal domain and via an N‐terminal zinc finger that binds polyA RNA specifically, facilitating efficient mRNA deadenylation by the intact Pan2–Pan3 complex.
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