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- Publications
- Influence
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- J. Z. Long, W. Li, +9 authors B. Cravatt
- Chemistry, Medicine
- Nature chemical biology
- 3 November 2008
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for… Expand
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.
- L. Heisler, H. M. Chu, +4 authors L. Tecott
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 8 December 1998
The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. To evaluate the… Expand
Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens.
- F. Weiss, C. S. Maldonado-Vlaar, L. Parsons, T. Kerr, D. Smith, O. Ben-shahar
- Medicine
- Proceedings of the National Academy of Sciences…
- 11 April 2000
The conditioning of the pharmacological actions of cocaine with environmental stimuli is thought to be a critical factor in the long-term addictive potential of this drug. Cocaine-related stimuli may… Expand
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
- D. Piomelli, A. Giuffrida, L. Parsons, F. Fonseca, M. Navarro
- Medicine
- 1 December 1999
Acute and Chronic Ethanol Alter Glutamatergic Transmission in Rat Central Amygdala: an In Vitro and In Vivo Analysis
- M. Roberto, P. Schweitzer, S. Madamba, D. Stouffer, L. Parsons, G. Siggins
- Chemistry, Medicine
- The Journal of Neuroscience
- 18 February 2004
The modulation of glutamatergic transmission by ethanol may contribute to ethanol intoxication, reinforcement, tolerance, and dependence. Therefore, we used in vitro electrophysiological and in vivo… Expand
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
- A. Giuffrida, L. Parsons, T. Kerr, F. R. Fonseca, M. Navarro, D. Piomelli
- Chemistry, Medicine
- Nature Neuroscience
- 1 April 1999
We measured endogenous cannabinoid release in dorsal striatum of freely moving rats by microdialysis and gas chromatography/mass spectrometry. Neural activity stimulated the release of anandamide,… Expand
Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats
- F. Weiss, L. Parsons, +4 authors G. Koob
- Medicine, Computer Science
- The Journal of Neuroscience
- 15 May 1996
TLDR
A genetic determinant of the striatal dopamine response to alcohol in men
- V. Ramchandani, J. Umhau, +14 authors M. Heilig
- Psychology, Medicine
- Molecular Psychiatry
- 19 April 2010
Excessive alcohol use, a major cause of morbidity and mortality, is less well understood than other addictive disorders. Dopamine release in ventral striatum is a common element of drug reward, but… Expand
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
- M. Talantova, S. Sanz-Blasco, +35 authors S. Lipton
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 17 June 2013
Significance Communication between nerve cells occurs at specialized cellular structures known as synapses. Loss of synaptic function is associated with cognitive decline in Alzheimer’s disease (AD).… Expand
Specific Alterations of Extracellular Endocannabinoid Levels in the Nucleus Accumbens by Ethanol, Heroin, and Cocaine Self-Administration
- S. Caille, L. Alvarez-Jaimes, I. Polis, D. Stouffer, L. Parsons
- Chemistry, Medicine
- The Journal of Neuroscience
- 4 April 2007
Ethanol and opiate self-administration are sensitive to manipulations of cannabinoid CB1 receptor function and, from this, a role for the endogenous cannabinoid system in the modulation of drug… Expand