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Carrageenan‐induced mouse paw oedema is biphasic, age‐weight dependent and displays differential nitric oxide cyclooxygenase‐2 expression
It is demonstrated that both eNOS and iNOS expressions are dependent upon the age-weight of mice, as opposite to COX‐2 that is present only in the second phase of the oedema and is not linked to mouse age–weight. Expand
Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids
- G. J. Blackwell, R. Carnuccio, M. Rosa, R. Flower, L. Parente, P. Persico
- Chemistry, Medicine
- 11 September 1980
It is reported that Macrocortin derived from rat peritoneal leukocytes is an intracellular polypeptide whose release and synthesis are stimulated by steroids. Expand
Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight.
It is proposed that the complexity of the situation in the field of COX-derived mediators should be borne in mind when anti-inflammatory therapy is required. Expand
Anti-inflammatory effects of annexin-1: stimulation of IL-10 release and inhibition of nitric oxide synthesis.
- V. Ferlazzo, P. D’Agostino, +4 authors L. Parente
- Chemistry, Medicine
- International immunopharmacology
- 1 October 2003
Results suggest that some of the anti-inflammatory effects of ANX-1 may be mediated by the release of IL-10, which, in turn, inhibits iNOS mRNA expression and, hence, NO release and, consequently, IL-12 synthesis. Expand
Annexin 1: more than an anti-phospholipase protein
Mimicking the action of glucocorticoids, ANXA1 promotes inflammatory cell apoptosis associated with transient rise in intracellular calcium and caspase-3 activation and may contribute to the anti-inflammatory signalling that allows safe post-apoptotic clearance of dead cells. Expand
Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo.
- M. Bucci, F. Roviezzo, +5 authors G. Cirino
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 18 January 2005
The data collectively support the critical role for eNOS in regulating the magnitude of the acute inflammatory response and show that eNos is critical for regulating microcirculatory endothelial barrier function in vivo. Expand
Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins.
- S. Getting, R. Flower, +5 authors M. Perretti
- Medicine, Chemistry
- The Journal of pharmacology and experimental…
- 1 October 1997
Data highlight a role for endogenous mast cells and for endothelial-derived selectins in MSU crystal-induced PMN recruitment into the peritoneal cavity, and may be useful to dissect molecular mechanism(s) which may be operating in gouty arthritis. Expand
Proteinase-Activated Receptor-2 Mediates Arterial Vasodilation in Diabetes
- F. Roviezzo, M. Bucci, +7 authors G. Cirino
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 November 2005
The data demonstrate an important role for PAR2 in modulating vascular arterial response in diabetes and suggest that this receptor could represent an useful therapeutic target. Expand
Secretagogue-specific effects of interleukin-1 on gastric acid secretion.
- J. Wallace, M. Cucala, K. Mugridge, L. Parente
- Biology, Medicine
- The American journal of physiology
- 1 October 1991
IL-1 beta is an extremely potent inhibitor of acid secretion stimulated by pentagastrin but not that stimulated by histamine or bethanechol, through a mechanism that is at least in part independent of the vagus nerve and of prostaglandin synthesis. Expand
IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein.
The authors show that induction of the Ax 1 protein and its translocation to the cell membrane are stimulated by interleukin 6, however neither IL-1 nor TNF-alpha display these effects, and suggest that Ax 1 may participate in host defence as a new acute class II phase protein. Expand