• Publications
  • Influence
Voltage-gated potassium channels as therapeutic targets
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in diverse physiological processes ranging from repolarization of neuronal and cardiac action potentials, to regulatingExpand
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Oncogenic potential of EAG K+ channels
We have investigated the possible implication of the cell cycle‐regulated K+ channel ether à go‐go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalianExpand
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  • Open Access
Overexpression of Eag1 potassium channels in clinical tumours
BackgroundCertain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern ofExpand
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  • Open Access
Voltage-gated potassium channels in cell proliferation.
  • L. Pardo
  • Medicine, Biology
  • Physiology
  • 1 October 2004
It is commonly accepted that cells require K(+) channels to proliferate. The role(s) of K(+) channels in the process is, however, poorly understood. Cloning of K(+) channel genes opened theExpand
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  • 16
  • Open Access
Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood–brain barrier integrity
In 2007, a multifaceted syndrome, associated with anti-NMDA receptor autoantibodies (NMDAR-AB) of immunoglobulin-G isotype, has been described, which variably consists of psychosis, epilepsy,Expand
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  • Open Access
Extracellular K+ specifically modulates a rat brain K+ channel.
Extracellular potassium concentration is actively maintained within narrow limits in all higher organisms. Slight variations in extracellular potassium levels can induce major alterations ofExpand
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Role of Voltage-gated Potassium Channels in Cancer
Ion channels are being associated with a growing number of diseases including cancer. This overview summarizes data on voltage-gated potassium channels (VGKCs) that exhibit oncogenic properties:Expand
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Functional expression of a rat homologue of the voltage gated either á go‐go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its
We have cloned a mammalian (rat) homologue of Drosophila ether á go‐go (eag) cDNA, which encodes a distinct type of voltage activated potassium (K) channel. The derived Drosophila and rat eagExpand
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C‐terminal domains implicated in the functional surface expression of potassium channels
A short C‐terminal domain is required for correct tetrameric assembly in some potassium channels. Here, we show that this domain forms a coiled coil that determines not only the stability but alsoExpand
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Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity.
The potassium channel ether à go-go has been directly linked to cellular proliferation and transformation, although its physiologic role(s) are as of yet unknown. The specific blockade of human Eag1Expand
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  • Open Access