L. Pais

Publications71
h-index14
Citations705
Highly Influential Citations8
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Modeling strategies for enantiomers separation by SMB chromatography
Modeling strategies for simulated moving bed adsorbers were studied to compare the simulated moving bed model (SMB) that considers the real shift of the injection and collection points to the true… Expand
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Modeling, simulation and operation of a simulated moving bed for continuous chromatographic separation of 1,1′-bi-2-naphthol enantiomers
Abstract The objective of this paper is to study the separation of enantiomers of 1,1′-bi-2-naphthol in 3,5-dinitrobenzoyl phenylglycine bonded to silica gel, using heptane–isopropanol (72:28) as… Expand
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Cyclic steady state of simulated moving bed processes for enantiomers separation
Abstract Simulated moving bed (SMB) technology developed by UOP in early 1960s has expanded greatly in the last decade, finding new applications in the area of natural products, fine chemistry and… Expand
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Separation of nadolol stereoisomers by chiral liquid chromatography at analytical and preparative scales.
The separation of the four nadolol stereoisomers on Chiralpak® AD by chiral liquid chromatography was carried out at both analytical and preparative scales. A screening of possible mobile-phase… Expand
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Separation of enantiomers of a chiral epoxide by simulated moving bed chromatography
Abstract The paper deals with chiral separation by simulated moving bed (SMB) chromatography. The separation of chiral epoxide enantiomers in microcrystalline cellulose triacetate using methanol as… Expand
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Design of simulated moving bed and Varicol processes for preparative separations with a low number of columns.
Simulated moving bed (SMB) chromatography has received significant attention in the last decade, particularly as regards the production of very valuable products, such as enantiomerically pure… Expand
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Separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane by liquid chromatography: laboratory-scale elution chromatography and modelling of simulated moving bed
Abstract The separation of enantiomers of 1 a ,2,7,7 a -tetrahydro-3-methoxynaphtha-(2,3 b )-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale.… Expand
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Chiral Separation of Ketoprofen Enantiomers by Preparative and Simulated Moving Bed Chromatography
The pharmaceutical industry is now directed to the market of more safety and efficient drugs, based on single enantiomers. Ketoprofen, still used as a racemic pharmaceutical drug, belongs to the… Expand
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Chiral separation of flurbiprofen enantiomers by preparative and simulated moving bed chromatography.
This study presents the chiral resolution of flurbiprofen enantiomers by preparative liquid chromatography using the simulated moving bed (SMB) technology. Flurbiprofen enantiomers are widely used as… Expand
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Preparative separation of ketoprofen enantiomers: choice of mobile phase composition and measurement of competitive adsorption isotherms
The present work intends to investigate how mobile phase composition influences the adsorption behavior of ketoprofen enantiomers (a nonsteroidal anti-inflammatory drug) on an amylose-based chiral… Expand
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