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Immunomodulatory effect of human adipose tissue‐derived adult stem cells: comparison with bone marrow mesenchymal stem cells
TLDR
It is supported that ADAS cells share immunosuppressive properties with BM‐MSCs, and therefore, ADAS cell‐based reconstructive therapy could employ allogenic cells and because of their immunosppressive properties,ADAS cells could be an alternative source to BM‐ MSCs to treat allogenic conflicts.
A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation
TLDR
Results strongly suggest that UCP2 is sensitive to GDP and that the UCPs, particularly U CP2, are able to modulate H2O2 mitochondrial generation, which supports a role for UCP1 in cellular (patho‐) physiological processes involving free radicals generated by mitochondria, such as oxidative damage, inflammation, or apoptosis.
Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization.
TLDR
The results demonstrate that adipocytes expressing UCP are present in adipose deposits considered as white fat, and suggest the existence of a continuum in rodents between BAT and WAT, and a great plasticity between adipose tissue phenotypes.
Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells: Physiological and Therapeutic Perspectives
TLDR
This study demonstrates, for the first time, that adipocytes and endothelial cells have a common progenitor, and highlights the concept that adipose lineage cells represent a suitable new cell source for therapeutic angiogenesis in ischemic disease.
Spontaneous Cardiomyocyte Differentiation From Adipose Tissue Stroma Cells
TLDR
It is demonstrated that functional cardiomyocyte-like cells could be directly obtained from adipose tissue according to the large amount of this tissue in adult mammal, which could represent a useful source of cardiomeocyte progenitors.
Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion
TLDR
It is demonstrated that mROS production is a necessary stimulus for glucose-induced insulin secretion by investigating the mitochondrial origin of ROS (mROS) as the triggering signal.
Glucose transporter 2 (GLUT 2): expression in specific brain nuclei
TLDR
It was demonstrated, using the polymerase chain reaction, that GLUT 2 mRNAs are present in a limited number of brain nuclei, including the nucleus tractus solitarius, the motor nucleus of the vagus, the paraventricular hypothalamic nucleus, the lateral hypothalamic area, the arcuate nucleus and the olfactory bulbs.
Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins
TLDR
It is proposed that UCPs could play a central role in modulation of ROS‐dependent signalling pathways and metabolic sensing via the modulation of oxygen concentration and ROS generation.
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat.
TLDR
A quantitative method allowing determination of glucose metabolism in vivo in muscles and white adipose tissue of the anaesthetized rat is presented and results corresponded qualitatively and quantitatively to the known physiological characteristics of the tissues studied.
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
TLDR
This study demonstrates that distinct combinations of genetic loci are responsible for different physiological characteristics associated with the diabetic phenotype in the GK rat, and it constitutes an important step for directing the search for the genetic factors involved in human NIDDM.
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