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Perinatal depression—The fourth inflammatory morbidity of pregnancy? Theory and literature review
Perinatal depression is one of the leading causes of maternal morbidity and mortality. The biological etiology of this disorder remains in question, despite considerable research into the
Bleeding Patterns After Immediate Initiation of an Oral Compared With a Vaginal Hormonal Contraceptive
TLDR
This study shows advantageous bleeding patterns for subjects using the contraceptive vaginal ring and confirms the previous findings that immediate start of hormonal contraception is an acceptable alternative to waiting for menses.
Acceptability and satisfaction using Quick Start with the contraceptive vaginal ring versus an oral contraceptive.
TLDR
Women who were allocated to vaginal ring use, regardless of their baseline characteristics or behavior, were likely to be highly satisfied with the method and to continue its use.
Preventing postpartum depression: review and recommendations
TLDR
Among biological studies, anti-depressants and nutrients provided the most evidence of successful intervention, and interpersonal therapy trials and trials that targeted an at-risk population appear to hold the most promise for further study.
Measured and reported weight change for women using a vaginal contraceptive ring vs. a low-dose oral contraceptive.
TLDR
Participants underreported their weight, and this difference was greater for heavier women, while participants' opinions about weight change were not correlated with measured weight changes.
Oxytocin receptor DNA methylation in postpartum depression
TLDR
The data corroborate the previous hypotheses of a PPD specific increased sensitivity of epigenetic reprogramming at estrogen target genes and suggests that OXTR epigenetic variation may be an important mediator of mood relevant neuroactive steroid production.
Associations Among Child Abuse, Depression, and Interleukin-6 in Pregnant Adolescents: Paradoxical Findings
TLDR
Depression severity distinguished IL- 6 levels among more severely abused pregnant Latina adolescents, but it was unrelated to IL-6 among less severely abused adolescents, and Cortisol explained the relationship betweenIL-6 and earlier gestational age at birth.
Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature
TLDR
Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroids physiology, such as synthetic enzymes or receptor plasticity.
The role of Th17 cells in the pathophysiology of pregnancy and perinatal mood and anxiety disorders
TLDR
Understanding the pathophysiology of perinatal mood and anxiety disorders will aid development of novel therapeutics that address immunological mechanisms, in addition to the serotonin system, which are targetable molecules in treating depression and anxiety during pregnancy.
Reproductive Psychiatry: The Gap Between Clinical Need and Education.
TLDR
Increased body of knowledge has led to the growth of international professional societies such as the Marcé International Society for Perinatal Mental Health and the International Society of Psychosomatic Obstetrics andGynecology and research resulting from these changes has dramatically expanded knowledge of the psychiatric sequelae of reproductive cycle transitions.
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