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Phylogenetic Classification and the Universal Tree
Of great interest in the etiological context, however, are recent demonstrations that, in contrast to previous belief, autoand cross-catalytic molecular replication with high turnover numbers can occur in the oligopeptide series.
Selfish DNA: the ultimate parasite
The DNA of higher organisms usually falls into two classes, one specific and the other comparatively nonspecific. It seems plausible that most of the latter originated by the spreading of sequences…
Prebiotic chemistry and the origin of the RNA world.
- L. Orgel
- BiologyCritical reviews in biochemistry and molecular…
- 1 March 2004
The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World, and a discussion of genetic systems simpler than RNA that might have "invented" RNA is discussed.
Evolution of the genetic apparatus.
- L. Orgel
- BiologyJournal of molecular biology
- 28 December 1968
The search for organic substances and inorganic volatile compounds in the surface of Mars
A total of four Martian samples, one surface and one subsurface sample at each of the two Viking landing sites, Chryse Planitia and Utopia Planitia, have been analyzed for organic compounds by a gas…
Studies in prebiotic synthesis. II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide.
CODES WITHOUT COMMAS.
Chiral selection in poly(C)-directed synthesis of oligo(G)
- G. F. Joyce, G. M. Visser, C. V. Boeckel, J. Boom, L. Orgel, J. Westrenen
- 16 August 1984
It is reported here that poly(C)-directed oligomerization of activated guanosine mononucleotides proceeds readily if the monomers are of the same optical handedness as the template, and is indeed far less efficient if theMonomers of the opposite handedness are involved.
2 Prospects for Understanding the Origin of the RNA World
The general idea that, in the development of life on the earth, evolution based on RNA replication preceded the appearance of protein synthesis was first proposed about 30 years ago and the existence of an RNA World as a precursor of the authors' DNA/protein world is a hypothesis.