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Correlation between insulin receptor occupancy and tyrosine kinase activity at low insulin concentrations and effect of major histocompatibility complex class I-derived peptide.
TLDR
The peptide-mediated inhibition of internalization, which doubles the number of insulin-occupied receptors at an insulin concentration of 70 pM, also results in a corresponding enhancement of PI kinase activity and glucose uptake, indicating that the receptors arrested on the cell surface by the peptide are biologically active. Expand
Antibody producing human-human hybridomas. I. Technical aspects.
TLDR
The yield of hybrids was significantly lower when normal peripheral blood lymphocytes were used as fusion partners as compared with spleen lymphocytes, but could be substantially improved by increasing the amount of mitotic active B-lymphocytes by mitogen stimulation of the lymphocytes prior to fusion. Expand
Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity.
  • L. Olsson, H. Kaplan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 September 1980
TLDR
It is reported the establishment of human-human hybridomas producing monoclonal antibody of predefined antigenic specificity from patients with untreated Hodgkin's disease who had been previously sensitized to the chemical allergen 2,4-dinitrochlorobenzne. Expand
The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility
TLDR
It is concluded that the MHC class I heavy chain and the tetrameric insulin receptor are structurally associated in the cell membrane and suggested that this association may occur by displacement of beta 2-microglobulin by the insulin receptor. Expand
Non-specific binding of protein-stabilized gold sols as a source of error in immunocytochemistry.
TLDR
It is argued that, albeit gold sols are stabilized against salt coagulation by adsorption of proteins and other stabilizing agents, "naked areas" are (constantly or intermittently) present on particle surfaces, available for interaction with cell and tissue components that have a high electrostatic affinity for the charged gold surface under prevailing experimental conditions. Expand
Antibody Producing Human-Human Hybridomas
TLDR
The technical difficulties and improvements of the human-human hybridoma system are reported on. Expand
Intratumoral phenotypic diversity of cloned human lung tumor cell lines and consequences for analyses with monoclonal antibodies
TLDR
It is concluded that intratumoral phenotypic diversity may have a severe negative impact on the use of monoclonal antibodies in cancer diagnosis/therapy and a mixture of antibodies may be more useful in tumor diagnosis than individual antibodies and perhaps even therapy. Expand
Natural polyclonality of spontaneous AKR leukemia and its consequences for so-called specific immunotherapy.
TLDR
The cytotoxicity of sera and lymphoid cells from healthy mice immunized with lymphoma cells from either treated or nontreated mice with leukemia grafts revealed that the tumor cells could be subdivided into four distinct antigenic types. Expand
Antibody-producing human-human hybridomas. III. Derivation and characterization of two antibodies with specificity for human myeloid cells.
TLDR
It is concluded that myeloid leukemogenesis may result in generation of cell surface expression of either new or abnormally processed molecules that are immunogenic in the autochthonous host. Expand
STUDIES ON THE REGULATION OF LYMPHOCYTE PRODUCTION IN THE MURINE THYMUS AND SOME EFFECTS OF A CRUDE THYMUS EXTRACT
Cell proliferation in the murine thymus was studied in vivo under normal conditions and from 0 to 24 hr after a single injection of a water‐soluble extract from mouse thymus, mouse spleen, and mouseExpand
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