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Comparison of inflammatory changes in established type II collagen- and adjuvant-induced arthritis using outbred Wistar rats.
Type II collagen- and adjuvant-induced arthritis in outbred Wistar rats were compared using parameters that measured the inflammatory response, cellular and humoral immunity, blood protein changes,… Expand
Correlation between mouse skin inflammation induced by arachidonic acid and eicosanoid synthesis
- J. Chang, R. Carlson, L. O'Neill–Davis, B. Lamb, Rajeshwar N. Sharma, A. Lewis
- Chemistry, Medicine
- 1 September 1986
We and others have shown that arachidonic acid (AA), when applied topically to ear surfaces, causes an intense acute inflammatory reaction within minutes (as measured by ear thickness). In this… Expand
Effect of a 5-lipoxygenase (5-LO)/cyclooxygenase (CO) inhibitor, WY-47, 288, on cutaneous models of inflammation
WY-47,288 (2-[(1-naphthalenyloxy)methyl]quinoline) demonstrated topical antiinflammatory activity in several animal models of skin inflammation. Application of WY-47,288 to mouse ear surfaces… Expand
Molecular Umbrella Conjugate for the Ocular Delivery of siRNA
- V. Janout, Lauren L. Cline, +10 authors S. Regen
- Chemistry, Medicine
- Bioconjugate chemistry
- 16 January 2014
The synthesis, computer modeling, and biological activity of an octawalled molecular umbrella short interfacing RNA (siRNA) conjugate is described. This molecular umbrella–siRNA conjugate exhibited… Expand
The effect of cyclooxygenase inhibition on the ocular hypotensive action of topical carbonic anhydrase inhibitors in rabbits.
Experiments were undertaken in normal albino rabbits to determine if cyclooxygenase inhibition by nonsteroidal anti-inflammatory drugs modified the ocular hypotensive activities of topically applied… Expand
Effects of oral aspirin and oxaprozin on the development of lupus-like disease in MRL/1 mice.
- R. Carlson, S. Gilman, T. G. Hodge, L. O'Neill–Davis, E. Blazek, A. Lewis
- Journal of immunopharmacology
We examined the effects of two prostaglandin synthetase inhibitors, aspirin and oxaprozin, on the development of lupus-like disease in MRL/1 mice. Daily oral administration of 100 mg/kg of these… Expand
Wy-41,770: An antiarthritic agent with immunomodulating properties
Immunomodulating activity of Wy-41,770 (5H-dibenzo[A,D]cyclohepten-5-ylidene) acetic acid.
The immunomodulatory effects of Wy-41,770 (5H-dibenzo[a,d]cyclohepten-5-ylidene) acetic acid, were compared to levamisole and indomethacin in several in vivo models. In the Jerne plaque assay,… Expand
The topical effects of Wy-41,195 [2-cyano-3-(methylamino)phenylamino] oxoacetic acid, sodium salt and disodium cromoglycate in the rat passive eyelid anaphylaxis.
Wy-41,195 demonstrated significant inhibitory effects (54-60%) when administered topically at 0.25-2% concentrations in a rat passive eyelid anaphylaxis assay. In contrast, topically applied disodium… Expand
Effects of thiazinamium chloride on histamine release from rat peritoneal mast cells and on phosphodiesterase activity in guinea pig lung.
- R. Carlson, L. O'Neill–Davis, J. Chang, A. Lewis
- International archives of allergy and applied…
The effect of thiazinamium Cl (TCl) on histamine release from rat peritoneal mast cells (RPMC) was investigated. Although TCl inhibited compound 48/80-induced histamine release moderately (IC50 value… Expand