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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points. Expand
Biological properties of extracellular vesicles and their physiological functions
TLDR
A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. Expand
Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies
TLDR
This review collates internationally generated information on metabolic syndrome, its many definitions and its associations with life‐threatening conditions including type 2 diabetes mellitus, cardiovascular disease and cancer, providing a foundation for future advancements on this topic. Expand
Three-dimensional cell culture: the missing link in drug discovery.
TLDR
2D and 3D culture approaches are reviewed and the strengths and relevance of each method are considered in the context of anti-cancer drug screening. Expand
Gene Expression Profiling
TLDR
Application of multiplex real-time RT-PCR using TaqMan probes in the analysis of relative expression levels of a novel tumor-associated gene CUG2 in cell lines and tissue samples is described. Expand
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
TLDR
In this position statement, basic and clinical scientists, as members of the International Society for Extracellular Vesicles (ISEV) and of the European Cooperation in Science and Technology (COST) program, summarize recent developments and the current knowledge of EV-based therapies. Expand
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
TLDR
This study confirms that multiple mechanisms contribute to Docetaxel resistance and the central transcription factor NF-κB plays an immensely important role in determining docetaxe-resistance which may represent an appropriate therapeutic target. Expand
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
TLDR
It is argued that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments and EV-TRACK, a crowdsourcing knowledgebase that centralizes EV biology and methodology, is described. Expand
miR‐34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression
TLDR
Intacellular and extracellular miRNAs related to docetaxel resistance are investigated related to castration resistant prostate cancer. Expand
Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis.
TLDR
Weighted gene coexpression network analysis (WGCNA) is a powerful 'guilt-by-association'-based method to extract coexpressed groups of genes from large heterogeneous messenger RNA expression data sets and a cluster of genes was found to correlate with prognosis exclusively for basal-like breast cancer. Expand
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