• Publications
  • Influence
Using the Single Prolonged Stress Model to Examine the Pathophysiology of PTSD
TLDR
This review examines studies in a rodent model of PTSD with the goal of identifying behavioral and physiological factors that predispose individuals to PTSD symptoms and unresolved questions that may be investigated using the model. Expand
Vagus nerve stimulation promotes generalization of conditioned fear extinction and reduces anxiety in rats
TLDR
Evidence is provided that VNS can promote generalization of extinction to other stimuli associated with a specific fear experience and the ability to generalize extinction and reduce anxiety makes VNS a potential candidate for use as an adjunctive strategy to improve the efficacy and tolerability of exposure-based therapies. Expand
Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies
TLDR
It is found that VNS accelerates extinction and prevents reinstatement of conditioned fear in rats, and is proposed that stimulation of the left cervical vagus nerve during exposure to conditioned cues signals the brain to store new memories just as epinephrine or emotional arousal would do, but bypasses the peripheral sympathetic “fight-or-flight” response. Expand
NMDA receptor antagonism with MK-801 impairs consolidation and reconsolidation of passive avoidance conditioning in adolescent rats: Evidence for a state dependent reconsolidation effect
TLDR
The results extend the consolidation/reconsolidation literature to adolescent animals and provide evidence that some deficits described as reconsolidation impairments may be more aptly considered state dependent retention deficits. Expand
Peripheral effects of vagus nerve stimulation on anxiety and extinction of conditioned fear in rats.
TLDR
Methyl scopolamine blocked the VNS-induced reduction in anxiety but did not interfere with VNS enhancement of extinction of conditioned fear, indicating that the anxiety-reducing effect of VNS is not necessary for the extinction enhancement. Expand
LXXV. The Significance of Myelin Sheath Degeneration for the Cochlear Nerve
TLDR
The present study is a continuation of the drug effects and also includes the effects of a bacterial toxin and certain dietary factors on the cochlear nerve. Expand
Cannabinoid Receptor 1 Gene by Cannabis Use Interaction on CB1 Receptor Density
TLDR
An assay to quantify CB1 in lymphocytes to determine how it relates to cannabis use in 58 daily cannabis users compared with 47 nonusers demonstrates a minimally invasive technique of CB1 quantification that holds promise for the use ofCB1 protein concentration, along with rs2023239 genotype, as a potential biomarker for susceptibility to Cannabis use. Expand
The M-Maze task: An automated method for studying fear memory in rats exposed to protracted aversive conditioning
TLDR
It is suggested that long-term assessment of extinction impairments would lead to a better understanding of the neurobiology of persistent fear and the screening for new therapies. Expand