L. Nilsson

Publications47
h-index15
Citations945
Highly Influential Citations18
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The bioanalytical challenge of determining unbound concentration and protein binding for drugs.
  • L. Nilsson
  • Chemistry, Medicine
  • Bioanalysis
  • 9 December 2013
Knowledge regarding unbound concentrations is of vital importance when exploring the PK and PD of a drug. The accurate and reproducible determination of plasma protein binding and unbound… Expand
  • 36
  • 3
Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography--electrochemical detection system.
A simple method based on high-performance liquid column chromatography with electro-chemical detection is described for the simultaneous determination of dopamine, 3,4-dihydroxyphenylacetic acid… Expand
  • 242
  • 2
Disposition of remoxipride in different species. Species differences in metabolism.
The pharmacokinetics and metabolism of the new antipsychotic agent remoxipride ((S)-(-)-3-bromo-N(-)[(1-ethyl-2-pyrrolidinyl)methyl]-2, 6-dimethoxybenzamide, FLA731(-), Roxiam, CAS 80125-14-0) was… Expand
  • 46
  • 2
Capillary microsampling of 25 µl blood for the determination of toxicokinetic parameters in regulatory studies in animals.
BACKGROUND Capillary microsampling (CMS) is a new technique for simplified collection, handling and analysis of small, exact volumes of liquid matrices. CMS was compared with conventional large… Expand
  • 78
  • 2
Direct quantification in bioanalytical LC-MS/MS using internal calibration via analyte/stable isotope ratio.
  • L. Nilsson, G. Eklund
  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 19 February 2007
The possibility to rationalize and simplify bioanalysis, without compromising the analytical quality, by omitting the calibration curves was studied. Using mass spectrometry (MS) and a stable isotope… Expand
  • 45
  • 2
Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
INTRODUCTION To assure drug safety, the investigation of the relationship between plasma concentration and drug-induced prolongation of the QT interval of the ECG is a challenge in drug discovery.… Expand
  • 45
  • 1
Optimization of a peak compression system for a remoxipride metabolite (FLA797) and its application to bioanalysis.
  • L. Nilsson
  • Chemistry, Medicine
  • Journal of chromatography
  • 7 February 1992
A peak compression system is optimized for FLA797 (I), a phenolic tertiary amine and a metabolite to the antipsychotic drug remoxipride. An application is described where this effect is used to give… Expand
  • 12
  • 1
Regulation of peak compression effects for substituted benzamides in reversed-phase liquid chromatography
Abstract The possibilities of regulating peak compression effects, i.e. , of making the analyte peak coelute with the system peak, were investigated for substituted benzamides. The changes in… Expand
  • 7
  • 1
A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.
INTRODUCTION Drug-induced QT interval prolongation may lead to ventricular arrhythmias. The aim of the study was to optimize QT interval data processing to quantify drug-induced QT interval… Expand
  • 30
  • 1
Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
INTRODUCTION The aim of the present study was to compare sensitivity in detecting the drug-induced QT interval prolongation in three dog models: conscious telemetered at sinus rhythm and conscious… Expand
  • 29
  • 1