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- Publications
- Influence
The bioanalytical challenge of determining unbound concentration and protein binding for drugs.
- L. Nilsson
- Chemistry, Medicine
- Bioanalysis
- 9 December 2013
Knowledge regarding unbound concentrations is of vital importance when exploring the PK and PD of a drug. The accurate and reproducible determination of plasma protein binding and unbound… Expand
Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography--electrochemical detection system.
- O. Magnusson, L. Nilsson, D. Westerlund
- Chemistry, Medicine
- Journal of chromatography
- 1 December 1980
A simple method based on high-performance liquid column chromatography with electro-chemical detection is described for the simultaneous determination of dopamine, 3,4-dihydroxyphenylacetic acid… Expand
Disposition of remoxipride in different species. Species differences in metabolism.
- M. Widman, L. Nilsson, B. Bryske, J. Lundström
- Biology, Medicine
- Arzneimittel-Forschung
- 1 March 1993
The pharmacokinetics and metabolism of the new antipsychotic agent remoxipride ((S)-(-)-3-bromo-N(-)[(1-ethyl-2-pyrrolidinyl)methyl]-2, 6-dimethoxybenzamide, FLA731(-), Roxiam, CAS 80125-14-0) was… Expand
Capillary microsampling of 25 µl blood for the determination of toxicokinetic parameters in regulatory studies in animals.
- O. Jonsson, Rodrigo Palma Villar, +5 authors A. Samuelsson
- Chemistry, Medicine
- Bioanalysis
- 28 March 2012
BACKGROUND
Capillary microsampling (CMS) is a new technique for simplified collection, handling and analysis of small, exact volumes of liquid matrices. CMS was compared with conventional large… Expand
Direct quantification in bioanalytical LC-MS/MS using internal calibration via analyte/stable isotope ratio.
- L. Nilsson, G. Eklund
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 19 February 2007
The possibility to rationalize and simplify bioanalysis, without compromising the analytical quality, by omitting the calibration curves was studied. Using mass spectrometry (MS) and a stable isotope… Expand
Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
- A. Ollerstam, S. Visser, +7 authors Ahmad Al-Saffar
- Medicine
- Journal of pharmacological and toxicological…
- 1 March 2006
INTRODUCTION
To assure drug safety, the investigation of the relationship between plasma concentration and drug-induced prolongation of the QT interval of the ECG is a challenge in drug discovery.… Expand
Optimization of a peak compression system for a remoxipride metabolite (FLA797) and its application to bioanalysis.
- L. Nilsson
- Chemistry, Medicine
- Journal of chromatography
- 7 February 1992
A peak compression system is optimized for FLA797 (I), a phenolic tertiary amine and a metabolite to the antipsychotic drug remoxipride. An application is described where this effect is used to give… Expand
Regulation of peak compression effects for substituted benzamides in reversed-phase liquid chromatography
- L. Nilsson
- Chemistry
- 11 May 1990
Abstract The possibilities of regulating peak compression effects, i.e. , of making the analyte peak coelute with the system peak, were investigated for substituted benzamides. The changes in… Expand
A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.
- A. Ollerstam, A. H. Persson, +8 authors Ahmad Al-Saffar
- Medicine
- Journal of pharmacological and toxicological…
- 2007
INTRODUCTION
Drug-induced QT interval prolongation may lead to ventricular arrhythmias. The aim of the study was to optimize QT interval data processing to quantify drug-induced QT interval… Expand
Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
- A. Ollerstam, S. Visser, +6 authors Ahmad Al-Saffar
- Medicine
- Journal of pharmacological and toxicological…
- 1 September 2007
INTRODUCTION
The aim of the present study was to compare sensitivity in detecting the drug-induced QT interval prolongation in three dog models: conscious telemetered at sinus rhythm and conscious… Expand