• Publications
  • Influence
The bioanalytical challenge of determining unbound concentration and protein binding for drugs.
  • L. Nilsson
  • Chemistry, Medicine
    Bioanalysis
  • 9 December 2013
TLDR
Different parameters affecting the equilibrium and analysis are discussed, together with suggestions on how to control these parameters in order to produce as trustworthy results for unbound concentrations/fractions as possible.
Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography--electrochemical detection system.
TLDR
Of the four different supports tested Nucleosil C15 (5 micron) was found superior with respect to chromatographic performance and the effects of pH, methanol and the ion-pairing agent hexyl sulfate on the retention were studied.
Disposition of remoxipride in different species. Species differences in metabolism.
TLDR
The pharmacokinetics and metabolism of the new antipsychotic agent remoxipride was studied in rodents, dogs and human subjects using the unlabelled or the labelled (3H or 14C) drug.
Capillary microsampling of 25 µl blood for the determination of toxicokinetic parameters in regulatory studies in animals.
TLDR
Presented data support that TK measurements can be performed in main study rats, instead of dosing additional satellite animals only for TK sampling, giving both a higher scientific value and a substantial reduction of animal numbers in preclinical development.
Direct quantification in bioanalytical LC-MS/MS using internal calibration via analyte/stable isotope ratio.
  • L. Nilsson, G. Eklund
  • Chemistry, Medicine
    Journal of pharmaceutical and biomedical analysis
  • 19 February 2007
TLDR
The possibility to rationalize and simplify bioanalysis, without compromising the analytical quality, by omitting the calibration curves was studied and it was shown that all four prerequisites above were fulfilled.
Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs.
TLDR
The assessment of the individual concentration-effect relationship and confounding factors such as hysteresis might provide a better prediction of the safety profiles of new drug candidates.
High-performance liquid chromatographic determination of epimers, impurities, and content of the glucocorticoid budesonide and preparation of primary standard.
TLDR
The proposed HPLC procedure is faster, more accurate, more precise, and more selective than the usual pharmacopeial methods for corticosteroids.
Optimization of a peak compression system for a remoxipride metabolite (FLA797) and its application to bioanalysis.
  • L. Nilsson
  • Chemistry, Medicine
    Journal of chromatography
  • 7 February 1992
A peak compression system is optimized for FLA797 (I), a phenolic tertiary amine and a metabolite to the antipsychotic drug remoxipride. An application is described where this effect is used to give
Regulation of peak compression effects for substituted benzamides in reversed-phase liquid chromatography
Abstract The possibilities of regulating peak compression effects, i.e. , of making the analyte peak coelute with the system peak, were investigated for substituted benzamides. The changes in
A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog.
TLDR
The conscious dog model detected significant increases in the QT interval for all test substances investigated, and it was considered advantageous to use plasma concentration as a covariate, as well as adjusting for vehicle effect and serial correlation in measurements.
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