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Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals
Summary The World Health Organization has declared SARS-CoV-2 virus outbreak a world-wide pandemic. However, there is very limited understanding on the immune responses, especially adaptiveExpand
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IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis
CD4+ helper T cells contribute to the induction and maintenance of antigen-specific CD8+ T cells. Their absence results in short-lived antigen-specific CD8+ T cells and defective secondary CD8+ TExpand
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Targeting human dendritic cell subsets for improved vaccines.
Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce andExpand
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Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction
T cells become dysfunctional when they encounter self antigens or are exposed to chronic infection or to the tumour microenvironment1. The function of T cells is tightly regulated by a combinationalExpand
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Co‐inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor‐Infiltrating Myeloid Cells Induces Dysfunction of Anti‐tumor CD8+ T Cells
SUMMARY The molecular mechanisms whereby CD8+ T cells become “exhausted” in the tumor microenvironment remain unclear. Programmed death ligand‐1 (PD‐L1) is upregulated on tumor cells and PD‐1‐PD‐L1Expand
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New checkpoints in cancer immunotherapy
  • L. Ni, C. Dong
  • Biology, Medicine
  • Immunological reviews
  • 1 March 2017
Immune responses must be fine‐tuned to allow effective clearance of invading pathogens, while maintain tolerance to self‐antigens. T cells are the major effector cells for fighting and killing tumorExpand
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New B7 Family Checkpoints in Human Cancers
  • L. Ni, Chen Dong
  • Biology, Medicine
  • Molecular Cancer Therapeutics
  • 1 July 2017
T cells are the main effector cells in immune response against tumors. The activation of T cells is regulated by the innate immune system through positive and negative costimulatory molecules.Expand
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Characterization of anti-viral immunity in recovered individuals infected by SARS-CoV-2
The WHO has declared SARS-CoV-2 outbreak a public health emergency of international concern. However, to date, there was hardly any study in characterizing the immune responses, especially adaptiveExpand
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A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts.
Mucosal immunoglobulin A (IgA) secreted by local plasma cells (PCs) is a critical component of mucosal immunity. Although IgA class switching can occur at mucosal sites, high-affinity PCs areExpand
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Concomitant Activation and Antigen Uptake via Human Dectin-1 Results in Potent Antigen-Specific CD8+ T Cell Responses
Dectin-1, a C-type lectin recognizing fungal and mycobacterial pathogens, can deliver intracellular signals that activate dendritic cells (DCs), resulting in initiation of immune responses andExpand
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